CAS 128-62-1

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-

Description:

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-, known by its CAS number 128-62-1, is a complex organic compound characterized by its unique structural features, including a fused isobenzofuranone core and a dioxoloisoquinoline moiety. This compound exhibits a range of functional groups, including methoxy and dioxole groups, which contribute to its chemical reactivity and potential biological activity. It is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. The stereochemistry indicated by the (5R) and (3S) designations suggests specific spatial arrangements of atoms, which can influence the compound's interactions in biological systems. Such compounds are often of interest in medicinal chemistry due to their potential pharmacological properties, including anti-inflammatory or anticancer activities. However, detailed studies are necessary to fully elucidate its properties and applications in various fields, including pharmaceuticals and organic synthesis.

Formula: C₂₂H₂₃NO₇

InChI: InChI=1/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18-;/m1./s1

InChI key: InChIKey=AKNNEGZIBPJZJG-MSOLQXFVSA-N

SMILES: O(C)C=1C=2[C@@](N(C)CCC2C=C3C1OCO3)([C@@]4(C=5C(C(=O)O4)=C(OC)C(OC)=CC5)[H])[H]

Synonyms:

• (-)-Narcotine
• (-)-α-Narcotine
• (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[ 4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
• 1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv.
• 1-α-Narcotine
• <span class="text-smallcaps">L</span>-α-Noscapine
• Capval
• Coscopin
• Coscotabs
• L-α-Noscapine
• Longactin
• Longatin
• Lyobex
• Methoxyhydrastine
• Narcompren
• Narcosine
• Narcotin
• Narcotussin
• Narkotin
• Nectadon
• Nicolane
• Nipaxon
• Noscapalin
• Noscapin
• Noscapina
• Noscapine
• Nsc 5366
• O-Methylarcotoline
• O-Methylnarcotoline
• Opian
• Opianin
• Opianine
• Terbenol
• Tusscapine
• Vadebex
• l-α-Narcotine
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
• (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
• (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
• 6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
• (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride
• 6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one
• tusseapine
• L-α-Narcotin
• l-alpha-2-methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1
• Hederix (free base)
• Vadebe
• Key-Tusscapine
• Narcotine (7CI, 8CI)
• 5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4
• Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
• (S)-6,7-DIMETHOXY-3-((R)-4-METHOXY-6-METHYL-5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)-3H-ISOBENZOFURAN-1-ONE
• NOSCAPINE (NARCOTINE) NATURALLY OCCURRIN G O
• 1-alpha-Narcotine
• Detusso
• Noscapine (100 mg)
• Noscapine (Narcotine) base
• Noscapine (base and/or unspecified salts)
• Ecasil
• S(R*,S*)-6,7-DIMETHOXY-3-(5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]-ISOQUINOLIN-5-YL)-1(3H)-ISOBENZOFURANONE
• (S,R)-NOSCAPINE
• [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone
• ,2,3,4-tetrahydroisoquinaline
• Gnoscopine [dl-form]
• Terial
• 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1(3h)-isobenzofuranon
• dl-Narcotine [dl-form]
• 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (9CI)
• alpha-Narcotine
• nsc5366
• 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone, [S-(R*,S*)]
• Noscapine (500 mg)
• 5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4
• Noscapal
• L-ALPHA-NARCOTINE

Noscapine Hydrochloride

CAS: 128-62-1, 219533-73-0, 912-60-7

Formula: C₂₂H₂₃NO₇·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 449.88

Ref: 3B-N0963

Noscapine

CAS: 128-62-1

Color and Shape: Neat

Ref: 61-FOR1232.00

Noscapine 1.0 mg/ml in Acetonitrile

CAS: 128-62-1

Color and Shape: Single Solution

Ref: 61-AMP1232.00-11

NOSCAPINE CRS

CAS: 128-62-1

NOSCAPINE CRS

Formula: C₂₂H₂₃NO₇

Color and Shape: Added Modified

Molecular weight: 413.4205

Ref: 41-N1300000

Noscapine

CAS: 128-62-1

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₂₂H₂₃NO₇

Color and Shape: White Powder

Molecular weight: 413.14745

Ref: 45-1474504

Noscapine

CAS: 128-62-1

Formula: C₂₂H₂₃NO₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 413.4205

Ref: IN-DA007O3K

Noscapine

CAS: 128-62-1

Formula: C₂₂H₂₃NO₇

Color and Shape: White To Off-White Solid

Molecular weight: 413.43

Ref: 4Z-N-061012

Noscapine-13C-d3

CAS: 128-62-1

Formula: CC₂₁H₂₀D₃NO₇

Color and Shape: White To Off-White Solid

Molecular weight: 417.44

Ref: 4Z-N-061001

Noscapine

CAS: 128-62-1

Color and Shape: Neat

Ref: 86-MM1232.00

Noscapine

Controlled Product

CAS: 128-62-1

Formula: C₂₂H₂₃NO₇

Color and Shape: Neat

Molecular weight: 413.42

Ref: 04-C15652400

Noscapine

CAS: 128-62-1

Applications Antitussive.
References Tsunoda, N., et al.: Xenobiotica, 9, 181 (1979), Dhalstroem, B., et al.: Eur. J. Clin. Pharmacol., 22, 535 (1982), Al-Yahya, M.A., et al.: Anal. Profiles Drug Subs., 11, 407 (1982),

Formula: C₂₂H₂₃NO₇

Color and Shape: White

Molecular weight: 413.42

Ref: TR-N882000

Noscapine base

CAS: 128-62-1

Noscapine base is a natural alkaloid compound, which is derived from the opium poppy, Papaver somniferum. This bioactive compound modulates the microtubule assembly in cells, impacting the dynamic instability of microtubules, which is crucial in mitosis and cell division. The resultant modulation disrupts microtubule function, thereby exerting a cytostatic effect that hampers the proliferation of malignant cells.

Formula: C₂₂H₂₃NO₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 413.43 g/mol

Ref: 3D-FN09246