CAS 128517-07-7

(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone

Description:

The chemical substance with the name "(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dithia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone" and CAS number "128517-07-7" is a complex organic compound characterized by its unique bicyclic structure, which incorporates multiple functional groups including oxo and thia moieties. The stereochemistry indicated by the (S) and (Z) designations suggests specific spatial arrangements of atoms, which can significantly influence the compound's reactivity and interactions. The presence of multiple alkyl groups, such as ethylidene and dipropan-2-yl, contributes to its hydrophobic characteristics, while the bicyclic framework may impart rigidity to the molecule. This compound is likely to exhibit interesting chemical properties, including potential biological activity, due to its intricate structure. Its applications could span various fields, including pharmaceuticals and materials science, although specific uses would depend on further research into its properties and behavior in different environments.

Formula: C₂₄H₃₆N₄O₆S₂

InChI: InChI=1/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17+,19+,20-/m0/s1

InChI key: OHRURASPPZQGQM-GCCNXGTGSA-N

SMILES: C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

Synonyms:

• Fr 901228
• Romidepsin
• (1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

Romidepsin

CAS: 128517-07-7

Romidepsin

Formula: C₂₄H₃₆N₄O₆S₂

Purity: ≥98%

Molecular weight: 540.7

Ref: 54-BUP04661

Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide

CAS: 128517-07-7

Formula: C₂₄H₃₆N₄O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 540.6958

Ref: IN-DA000Y5C

Romidepsin

Controlled Product

CAS: 128517-07-7

Applications Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),

Formula: C₂₄H₃₆N₄O₆S₂

Color and Shape: Neat

Molecular weight: 540.7

Ref: TR-R425060

Romidepsin

CAS: 128517-07-7

Romidepsin (NSC-630176), an IV histone deacetylase inhibitor, treats refractory cutaneous/peripheral T-cell lymphomas.

Formula: C₂₄H₃₆N₄O₆S₂

Purity: 99.4% - 99.99%

Color and Shape: Solid

Molecular weight: 540.7

Ref: TM-T6006

Romidepsin

CAS: 128517-07-7

Formula: C₂₄H₃₆N₄O₆S₂

Molecular weight: 540.69

Ref: 4Z-R-160001

Romidepsin

CAS: 128517-07-7

(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentaone

Formula: C₂₄H₃₆N₄O₆S₂

Purity: 99%

Molecular weight: 540.7

Ref: IN-DG243733

Romidepsin

CAS: 128517-07-7

Natural anti-cancer agent; inhibitor of histone deacetylases

Formula: C₂₄H₃₆N₄O₆S₂

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 540.7 g/mol

Ref: 3D-FR10656

Romidepsin - Bio-X ™

CAS: 128517-07-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₄H₃₆N₄O₆S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 540.7 g/mol

Ref: 3D-BR300116

Romidepsin

CAS: 128517-07-7

Formula: C₂₄H₃₆N₄O₆S₂

Molecular weight: 540.7

Ref: BE-RMCR110000

Romidepsin

CAS: 128517-07-7

Purity: 98%

Molecular weight: 540.69

Ref: 10-F979349

Romidepsin-d8

Controlled Product

CAS: 128517-07-7

Applications Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),

Formula: C₂₄D₈H₂₈N₄O₆S₂

Color and Shape: Neat

Molecular weight: 548.745

Ref: TR-R425062

Romidepsin

CAS: 128517-07-7

Formula: C₂₄H₃₆N₄O₆S₂

Molecular weight: 540.7

Ref: ST-EA-CP-R56000