CAS 129722-12-9

Aripiprazole

Description:

Aripiprazole is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar disorder, and as an adjunct in major depressive disorder. It functions as a partial agonist at dopamine D2 receptors and serotonin 5-HT1A receptors, while also acting as an antagonist at 5-HT2A receptors, which contributes to its unique pharmacological profile. This mechanism helps to stabilize mood and reduce psychotic symptoms. Aripiprazole is characterized by its relatively low sedative effects compared to other antipsychotics, making it a preferred option for some patients. The substance is typically administered orally, but can also be given via intramuscular injection. Its chemical structure includes a quinolinone core, which is essential for its activity. Aripiprazole is generally well-tolerated, though it may cause side effects such as akathisia, weight gain, and metabolic changes in some individuals. As with any medication, it is important for patients to be monitored for efficacy and adverse effects during treatment.

Formula: C₂₃H₂₇Cl₂N₃O₂

InChI: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)

InChI key: InChIKey=CEUORZQYGODEFX-UHFFFAOYSA-N

SMILES: O(CCCCN1CCN(CC1)C2=C(Cl)C(Cl)=CC=C2)C=3C=C4C(=CC3)CCC(=O)N4

Synonyms:

• 2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
• 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]Butoxy]-3,4-Dihydrocarbostyril
• 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
• 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
• Abilify
• Abilitat
• Aripiperazole
• Aripiprazol
• Aripiprizole
• Aripirazole
• Aristab
• Arpizol
• Asprito
• Biopiprazole
• Opc 14597
• Opc 31
• Pripiprazole
• Aripiprazole
• OPC 31-d8-
• ARIPIPRAZOLE-D8
• OPC-14597, OPC-31,
• Abilify-d8
• Abilitat-d8
• Alipiprazole
• 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydro-2(1H)-quinolinone
• 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydrocarbostyril
• 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
• OPC 14597-d8

Aripiprazole

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 448.39

Ref: 3B-A2496

Aripiprazole 1.0 mg/ml in Acetonitrile

CAS: 129722-12-9

Color and Shape: Single Solution

Ref: 61-AMP0961.00-11

Aripiprazole

CAS: 129722-12-9

Color and Shape: Neat

Ref: 61-FOR0961.00

Aripiprazole

CAS: 129722-12-9

Color and Shape: Off-White

Ref: LP-ARP-1374-10

Aripiprazole, 1mg/ml in Acetonitrile

CAS: 129722-12-9

Color and Shape: Single Solution

Ref: LP-ARP-1374-1LA

ARIPIPRAZOLE CRS

CAS: 129722-12-9

ARIPIPRAZOLE CRS

Formula: C₂₃H₂₇Cl₂N₃O₂

Color and Shape: White. Whitish. Crystalline Powder.

Molecular weight: 448.3854

Ref: 41-Y0001649

Aripiprazole

CAS: 129722-12-9

Aripiprazole

Formula: C₂₃H₂₇Cl₂N₃O₂

Purity: 98.8%

Color and Shape: Off-White

Molecular weight: 447.14803

Ref: 47-1318

Aripiprazole impurity standard

CAS: 129722-12-9

Aripiprazole impurity standard

Color and Shape: Off-White

Ref: 47-1319

Aripiprazole

CAS: 129722-12-9

Lactams, nesoi

Formula: C₂₃H₂₇Cl₂N₃O₂

Color and Shape: White Pale Yellow Powder

Molecular weight: 447.14803

Ref: 45-1042634

7-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinol in-2-one

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 448.3854

Ref: IN-DA000TMF

Aripiprazole

CAS: 129722-12-9

Aripiprazole (OPC-14597) is a piperazine/quinolone antipsychotic, partial agonist at 5-HT1A/D2, and antagonist at 5-HT2A.

Formula: C₂₃H₂₇Cl₂N₃O₂

Purity: 99.43% - 99.62%

Color and Shape: Colourless Flake Crystalline Solid

Molecular weight: 448.39

Ref: TM-T1566

Aripiprazole

CAS: 129722-12-9

Aripiprazole

Purity: ≥98%

Molecular weight: 448.39g/mol

Ref: 54-BUP17124

Aripiprazole

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 448.39

Ref: 7W-GP6754

Aripiprazole

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 448.39

Ref: 4Z-A-142

Aripiprazole

CAS: 129722-12-9

Aripiprazole

Purity: 99%

Molecular weight: 448.39g/mol

Ref: 54-OR1028598

Aripiprazole

CAS: 129722-12-9

Color and Shape: Neat

Ref: 86-MM0961.00

Aripiprazole

Controlled Product

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Color and Shape: Neat

Molecular weight: 448.39

Ref: 04-C10300210

Aripiprazole RS

CAS: 129722-12-9

Color and Shape: White

Ref: 2K-1010100021

Aripiprazole

Controlled Product

CAS: 129722-12-9

Applications Aripiprazole is an agonist at the dopamine autoreceptor and an antagonist at the postsynaptic D2 receptor (1,2,3,4). Aripiprazole is an antipsychotic and a potential drug candidate for treating psychoses such as schizophrenia.
References (1) Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998)(2) Shiokawa, M., et al.: Eur.J.Pharmacol. 570, 108 (2007)(3) Oshiro, Y., et al.: J. Med. Chem. 41, 658 (1998)(4) Ozdemir, V., et al.: Curr Opin Investig Drugs. 3, 113 (2002)

Formula: C₂₃H₂₇Cl₂N₃O₂

Color and Shape: Neat

Molecular weight: 448.39

Ref: TR-A771000

Aripiprazole

CAS: 129722-12-9

Formula: C₂₃H₂₇Cl₂N₃O₂

Ref: TR-TRC-A771000