CAS 130663-39-7

(6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid

Description:

The chemical substance with the name "(6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid" and CAS number "130663-39-7" is characterized by its complex molecular structure, which includes an imidazopyridine core, a carboxylic acid functional group, and a dimethylamino-substituted aromatic ring. This compound exhibits properties typical of heterocyclic compounds, including potential biological activity due to its ability to interact with various biological targets. The presence of the dimethylamino group suggests it may have basic properties, while the carboxylic acid group can contribute to its solubility in polar solvents. Additionally, the bulky diphenylacetyl substituent may influence its pharmacokinetic properties, such as absorption and distribution. Overall, this compound's unique structural features may render it of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways.

Formula: C₃₁H₃₂N₄O₃

InChI: InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1

InChI key: InChIKey=YSTVFDAKLDMYCR-NDEPHWFRSA-N

SMILES: C(N1C2=C(CN(C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@H](C(O)=O)C2)N=C1)C5=CC(C)=C(N(C)C)C=C5

Synonyms:

• (6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
• (6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate)
• (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
• (S)-(+)-Pd 123319
• 1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
• 1H-Imidazo(4,5-c)pyridine-6-carboxylic acid, 1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-, (S)-
• 1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
• 1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
• Pd 123319

(6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid

CAS: 130663-39-7

Formula: C₃₁H₃₂N₄O₃

Purity: 98%

Molecular weight: 508.6108

Ref: IN-DA000US2

PD 123319

CAS: 130663-39-7

PD 123319

Purity: ≥95%

Molecular weight: 508.61g/mol

Ref: 54-BUP13085

PD 123319

CAS: 130663-39-7

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

Formula: C₃₁H₃₂N₄O₃

Purity: 98.61% - 99.65%

Color and Shape: Solid

Molecular weight: 508.61

Ref: TM-T6067

PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate

Controlled Product

CAS: 130663-39-7, 136676-91-0

Applications A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
References Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);

Formula: C₃₁H₃₂N₄O₃·2C₂HF₃O₂·xH₂O

Color and Shape: Neat

Molecular weight: 736.66 (anhydrous salt)

Ref: TR-P217475

PD 123319

CAS: 130663-39-7

Angiotensin receptor AT2 antagonist

Formula: C₃₁H₃₂N₄O₃

Purity: Min. 95%

Molecular weight: 508.61 g/mol

Ref: 3D-FP137709