CAS 13086-84-5

Di-tert-butyl phosphite

Description:

Di-tert-butyl phosphite is an organophosphorus compound characterized by its phosphite functional group, where two tert-butyl groups are attached to a phosphorus atom. It is typically a colorless to pale yellow liquid with a mild odor. This compound is known for its role as a stabilizer and antioxidant in various chemical processes, particularly in the production of polymers and plastics. Di-tert-butyl phosphite exhibits good thermal stability and can act as a reducing agent. Its chemical structure contributes to its relatively low volatility and moderate solubility in organic solvents. Additionally, it is sensitive to moisture and can hydrolyze in the presence of water, leading to the formation of phosphonic acids. Safety considerations include its potential to cause irritation upon contact with skin or eyes, and it should be handled with appropriate precautions in a well-ventilated area. Overall, di-tert-butyl phosphite is valued in industrial applications for its protective properties against oxidative degradation.

Formula: C₈H₁₉O₃P

InChI: InChI=1/C8H19O3P/c1-7(2,3)10-12(9)11-8(4,5)6/h12H,1-6H3

InChI key: InChIKey=HLMXUWAUCZMWOG-UHFFFAOYSA-N

SMILES: O(C(C)(C)C)P(OC(C)(C)C)=O

Synonyms:

• 2-Methyl-2-[(2-methylpropan-2-yl)oxyphosphonoyloxy]propane
• Di-Tert-Butoxy(Oxo)Phosphonium
• Di-Tert-Butyl Hydrogen Phosphite
• Di-Tert-Butyl Phosphonate
• Phosphonic acid, bis(1,1-dimethylethyl) ester
• Phosphonic acid, di-tert-butyl ester
• Phosphorous acid di-tert-butyl ester
• tert-Butyl phosphite ((C₄H₉O)₂P(OH))
• tert-Butyl phosphonate ((C₄H₉O)₂PH(O))
• Di-tert-butyl phosphite
• tert-Butyl phosphonate ((C4H9O)2PH(O))
• Di-tert-butyl phosphite 95%
• Einecs 235-996-8
• Ditertiarybutyl phosphite
• bis(1,1-dimethylethyl) phosphonate
• Di-tert-butyl phosphite ,97.5%
• Bis(2-methyl-2-propanyl) phosphonate

Di-tert-butyl Phosphonate

CAS: 13086-84-5

Formula: C₈H₁₉O₃P

Purity: >98.0%(T)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 194.21

Ref: 3B-D5814

Di-tert-butyl phosphite, 95%

CAS: 13086-84-5

As a solvent, as an antioxidant, and as an intermediate

Formula: C₈H₁₈O₃P

Purity: 95%

Color and Shape: Clear colorless to yellow, Liquid

Molecular weight: 193.20

Ref: 02-030233

Phosphonic acid, bis(1,1-dimethylethyl) ester

CAS: 13086-84-5

Formula: C₈H₁₉O₃P

Purity: 95%

Color and Shape: Liquid

Molecular weight: 194.2084

Ref: IN-DA000V16

Di-tert-butyl phosphonate

CAS: 13086-84-5

Di-tert-butyl phosphonate

Formula: C₈H₁₉O₃P

Purity: 99%

Color and Shape: clear. almost colourless liquid

Molecular weight: 194.21g/mol

Ref: 54-OR75599

Di-tert-butylphosphite

CAS: 13086-84-5

Di-tert-butylphosphite is a phosphatase inhibitor that is used as a synthetic target in drug discovery. Di-tert-butylphosphite binds to the active site of phosphatases and prevents them from hydrolyzing the phosphate group from their substrates. This leads to an accumulation of the substrate and a decrease in enzymes, which inhibits protein synthesis. The sequence specificity of di-tert-butylphosphite has been shown by its affinity for tripeptides with hydrophobic amino acids at position P1 and P3. Di-tert-butylphosphite has been shown to inhibit cancer cell growth in vitro by binding to DNA and inhibiting RNA synthesis. It also inhibits farnesyl diphosphate synthase, which synthesizes the precursor for cholesterol biosynthesis, leading to decreased levels of cholesterol and reduced cell proliferation.

Formula: C₈H₁₉O₃P

Purity: Min. 95 Area-%

Color and Shape: Clear Liquid

Molecular weight: 194.21 g/mol

Ref: 3D-FD153843

Di-tert-butylphosphite

CAS: 13086-84-5

Formula: C₈H₁₉O₃P

Purity: 95%

Color and Shape: Liquid

Molecular weight: 194.211

Ref: 10-F044564

Di-tert-butyl Phosphite

Controlled Product

CAS: 13086-84-5

Applications Di-tert-butyl Phosphite is used as a reagent in the synthesis of chloromethyl di-tert-butyl phosphate, a key component in the formation of many phosphonoxymethyl pro-drugs. Also used as a reagent in the synthesis of L-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zheng, B., et al.: Org. Process Res. Dev., 18, 636 (2014); Chauhan, S.S., et al.: Tetrahedron Lett., 48, 4051 (2007)

Formula: C₈H₁₉O₃P

Color and Shape: Neat

Molecular weight: 194.21

Ref: TR-D429515