CAS 130929-57-6
:Entacapone
Description:
Entacapone is a chemical compound primarily used as a medication in the treatment of Parkinson's disease. It functions as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme that metabolizes levodopa, thereby enhancing the effectiveness of levodopa therapy. The molecular formula of entacapone is C14H15N3O5, and it has a molecular weight of approximately 289.29 g/mol. The compound appears as a yellow to orange crystalline powder and is typically administered orally. Entacapone is known for its ability to prolong the action of levodopa by preventing its breakdown, which helps to manage motor symptoms associated with Parkinson's disease. It is often used in combination with other medications, such as carbidopa and levodopa, to improve patient outcomes. The substance is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances and dyskinesia. As with any medication, it is important for patients to consult healthcare professionals regarding its use and potential interactions with other drugs.
Formula:C14H15N3O5
InChI:InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
InChI key:InChIKey=JRURYQJSLYLRLN-BJMVGYQFSA-N
SMILES:C(=C(/C(N(CC)CC)=O)\C#N)\C1=CC(N(=O)=O)=C(O)C(O)=C1
Synonyms:- (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
- (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
- (E)-Entacapone
- 2-Cyano-3-(5-Dihydroxyamino-3,4-Dioxo-1-Cyclohexa-1,5-Dienyl)-N,N-Diethyl-Prop-2-Enamide
- 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
- 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-
- Comtan
- Comtess
- Entacom
- Or 611
- Parkicapone
- See more synonyms
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Found 15 products.
Entacapone
CAS:Nitrile function compounds, nesoiFormula:C14H15N3O5Color and Shape:Yellow Green Crystalline PowderMolecular weight:305.10117(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
CAS:Formula:C14H15N3O5Purity:95%Color and Shape:SolidMolecular weight:305.2860Entacapone
CAS:Formula:C14H15N3O5Purity:99.0 - 101.0 % (dried basis)Color and Shape:Green-yellow to yellow powderMolecular weight:305.29Entacapone-d10(N,N-diethyl-d10)
CAS:Purity:99 atom % DColor and Shape:Yellow To Brown SolidMolecular weight:315.35Entacapone
CAS:<p>Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).</p>Formula:C14H15N3O5Purity:98.80% - >99.99%Color and Shape:Yellow Crystalline SolidMolecular weight:305.29Entacapone
CAS:Controlled Product<p>Applications (E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992); Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992); Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993);<br></p>Formula:C14H15N3O5Color and Shape:Off WhiteMolecular weight:305.29Entacapone
CAS:Controlled ProductCatechol-O-methyltransferase inhibitorFormula:C14H15N3O5Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:305.29 g/mol
