CAS 131563-73-0

10-hydroxymorphine

Description:

10-Hydroxymorphine is a semi-synthetic derivative of morphine, characterized by the presence of a hydroxyl group at the 10-position of the morphine structure. This modification alters its pharmacological properties compared to its parent compound. The substance exhibits analgesic effects, similar to morphine, but may have different potency and side effect profiles. It is classified as an opioid and interacts with the central nervous system, primarily through mu-opioid receptors, leading to pain relief and potential for dependence. The chemical structure of 10-hydroxymorphine contributes to its solubility and stability, influencing its formulation in pharmaceutical applications. Additionally, it is important to consider its legal status and potential for abuse, as it falls within the category of controlled substances in many jurisdictions. Research into its therapeutic uses and safety profile continues, as understanding its characteristics can aid in developing effective pain management strategies while minimizing risks associated with opioid use.

Formula: C₁₇H₁₉NO₄

InChI: InChI=1/C17H19NO4/c1-18-7-6-17-9-3-5-11(20)16(17)22-15-10(19)4-2-8(12(15)17)14(21)13(9)18/h2-5,9,11,13-14,16,19-21H,6-7H2,1H3/t9-,11-,13-,14-,16-,17-/m0/s1

InChI key: ISVKWTNAIRJURI-NGQSNTBFSA-N

SMILES: CN1CC[C@]23[C@H]4C=C[C@@H]([C@@H]3Oc3c(ccc(c23)[C@@H]([C@@H]14)O)O)O

Synonyms:

• 10 alpha-Hydroxymorphine
• Morphinan-3,6,10-triol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha,10alpha)-
• (5Alpha,6Alpha,10Alpha)-17-Methyl-7,8-Didehydro-4,5-Epoxymorphinan-3,6,10-Triol
• 10-Hydroxymorphine

7,8-Didehydro-4,5α-epoxy-17-methylmorphinan-3,6α,10α-triol (10S-Hydroxymorphine)

Controlled Product

CAS: 131563-73-0

Formula: C₁₇H₁₉NO₄

Color and Shape: Neat

Molecular weight: 301.34

Ref: 86-MM0037.27

10alpha-Hydroxymorphine

Controlled Product

CAS: 131563-73-0

Applications An impurity in the synthesis of morphine, with pharmaceutical properties similar to that of morphine.
References Farsam, H., et al.: Pharm. Res., 7, 1205 (1990);

Formula: C₁₇H₁₉NO₄

Color and Shape: Neat

Molecular weight: 301.34

Ref: TR-H948720

10-Hydroxymorphine solution

Controlled Product

CAS: 131563-73-0

10-Hydroxymorphine is a narcotic analgesic that is structurally related to codeine. It has been shown to be effective in the management of chronic pain, as well as in the treatment of heroin withdrawal symptoms. 10-Hydroxymorphine is used to relieve moderate to severe pain and suppress coughs. This drug is a prodrug that is metabolized by the liver into morphine, which has potent analgesic properties. Thebaine, one of the major impurities in 10-hydroxymorphine, can be detected using a spectrometer with an nmr spectrum at 500 MHz. This impurity can be removed by reaction monitoring or by using an excipient such as hydrochloric acid or sodium hydroxide to neutralize it.

Formula: C₁₇H₁₉NO₄

Purity: Min. 95%

Molecular weight: 301.34 g/mol

Ref: 3D-GFA56373