CAS 132203-70-4

Cilnidipine

Description:

Cilnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists and exhibits a dual mechanism of action by blocking both L-type and N-type calcium channels. This unique property allows cilnidipine to not only reduce vascular resistance and lower blood pressure but also to provide neuroprotective effects by inhibiting neurotransmitter release in the sympathetic nervous system. Cilnidipine is typically administered orally and is known for its long duration of action, which contributes to improved patient compliance. The substance is characterized by its relatively high lipophilicity, which influences its absorption and distribution in the body. Common side effects may include dizziness, flushing, and peripheral edema, similar to other calcium channel blockers. Its pharmacokinetics involve hepatic metabolism, primarily through cytochrome P450 enzymes, and it is excreted mainly via urine. Overall, cilnidipine represents a valuable therapeutic option in managing high blood pressure, particularly in patients who may benefit from its unique pharmacological profile.

Formula: C₂₇H₂₈N₂O₇

InChI: InChI=1/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChI key: InChIKey=KJEBULYHNRNJTE-DHZHZOJONA-N

SMILES: C(OC/C=C/C1=CC=CC=C1)(=O)C=2C(C(C(OCCOC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3

Synonyms:

• (+/-)-(E)-Cinnamyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
• (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl acetate
• (±)-Frc 8653
• 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-({[(2E)-3-phenylprop-2-en-1-yl]oxy}methyl)-1,4-dihydropyridine-3-carboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
• Atelec
• Cilacar 10
• Cinaldipine
• Cinalong
• Frg 8653

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester

CAS: 132203-70-4

Formula: C₂₇H₂₈N₂O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 492.5204

Ref: IN-DA0010DR

Cilnidipine

CAS: 132203-70-4

Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

Formula: C₂₇H₂₈N₂O₇

Purity: 98.85% - 99.83%

Color and Shape: Yellow Crystalline Solid

Molecular weight: 492.52

Ref: TM-T0388

Cilnidipine-d7

CAS: 132203-70-4

Formula: C₂₇H₂₁D₇N₂O₇

Color and Shape: Off-White Solid

Molecular weight: 499.57

Ref: 4Z-C-166006

Cilnidipine

CAS: 132203-70-4

Formula: C₂₇H₂₈N₂O₇

Color and Shape: Pale Yellow Solid

Molecular weight: 492.53

Ref: 4Z-C-166001

Cilnidipine

CAS: 132203-70-4

Cilnidipine

Purity: ≥98%

Molecular weight: 492.52g/mol

Ref: 54-BUP14492

Cilnidipine

CAS: 132203-70-4

Cilnidipine

Purity: 99%

Molecular weight: 492.52g/mol

Ref: 54-OR1027071

Cilnidipine

CAS: 132203-70-4

Formula: C₂₇H₂₈N₂O₇

Molecular weight: 492.52

Ref: 7W-GP6753

Cilnidipine

CAS: 132203-70-4

Formula: C₂₇H₂₈N₂O₇

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 492.53

Ref: 3B-C2564

Cilnidipine-d3

CAS: 132203-70-4

Formula: C₂₇H₂₅D₃N₂O₇

Molecular weight: 495.55

Ref: 4Z-C-166005

Cilnidipine RS

CAS: 132203-70-4

Color and Shape: Light Yellow Solid Crystalline Powder

Ref: 2K-1070600021

Cilnidipine

Controlled Product

CAS: 132203-70-4

Applications A dihydropyridine calcium channel blocker.
References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992), Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992), Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993),

Formula: C₂₇H₂₈N₂O₇

Color and Shape: Neat

Molecular weight: 492.52

Ref: TR-C441375

Cilnidipine-d3

Controlled Product

CAS: 132203-70-4

Applications Isotope labelled Clindipine (C441375), a dihydropyridine calcium channel blocker.
References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992), Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992), Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993

Formula: C₂₇D₃H₂₅N₂O₇

Color and Shape: Neat

Molecular weight: 495.539

Ref: TR-C441377

Cilnidipine

CAS: 132203-70-4

Inhibits L- and N-type calcium channels; anti-hypertensive; neuroprotective

Formula: C₂₇H₂₈N₂O₇

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 492.52 g/mol

Ref: 3D-FC20435

Cilnidipine - Bio-X ™

CAS: 132203-70-4

Clinidipine is a dihydropyridine calcium channel blocker that is used to treat hypertension. This drug acts on L-type calcium channels of blood vessels by blocking calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. . Cilnidipine also shows activity against N-type calcium channels.

Formula: C₂₇H₂₈N₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 492.52 g/mol

Ref: 3D-BC164309

CILNIDIPINE

CAS: 132203-70-4

Purity: 99%

Molecular weight: 492.5280151

Ref: 10-F800857