CAS 132203-70-4: Cilnidipine

Description:Cilnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists and exhibits a dual mechanism of action by blocking both L-type and N-type calcium channels. This unique property allows cilnidipine to not only reduce vascular resistance and lower blood pressure but also to provide neuroprotective effects by inhibiting neurotransmitter release in the sympathetic nervous system. Cilnidipine is typically administered orally and is known for its long duration of action, which contributes to improved patient compliance. The substance is characterized by its relatively high lipophilicity, which influences its absorption and distribution in the body. Common side effects may include dizziness, flushing, and peripheral edema, similar to other calcium channel blockers. Its pharmacokinetics involve hepatic metabolism, primarily through cytochrome P450 enzymes, and it is excreted mainly via urine. Overall, cilnidipine represents a valuable therapeutic option in managing high blood pressure, particularly in patients who may benefit from its unique pharmacological profile.

Formula:C₂₇H₂₈N₂O₇

InChI:InChI=1/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChI key:InChIKey=KJEBULYHNRNJTE-DHZHZOJONA-N

SMILES:O=C(OCC=CC=1C=CC=CC1)C2=C(NC(=C(C(=O)OCCOC)C2C=3C=CC=C(C3)N(=O)=O)C)C

Synonyms:
(+/-)-(E)-Cinnamyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl acetate
(±)-Frc 8653
2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-({[(2E)-3-phenylprop-2-en-1-yl]oxy}methyl)-1,4-dihydropyridine-3-carboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
Atelec
Cilacar 10
See more synonyms
Cinaldipine
Cinalong
Frg 8653
Siscard

Found 15 products.

Product data	Purity	Price range	Estimated delivery
Cilnidipine REF: 3B-C2564CAS: 132203-70-4	>98.0%(HPLC)	51.00 €~148.00 €	Mon 07 Apr 25
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester REF: IN-DA0010DRCAS: 132203-70-4	99%	To inquire	Mon 14 Apr 25
Cilnidipine REF: TM-T0388CAS: 132203-70-4	100% - 99.83%	48.00 €~164.00 €	Mon 14 Apr 25
Cilnidipine REF: 4Z-C-166001CAS: 132203-70-4	- - -	To inquire	Tue 15 Apr 25
Cilnidipine REF: 54-BUP14492CAS: 132203-70-4	99.9%	132.00 €~538.00 €	Tue 15 Apr 25
Cilnidipine REF: 54-OR1027071CAS: 132203-70-4	- - -	38.00 €~2,354.00 €	Tue 15 Apr 25
Cilnidipine-d7 REF: 4Z-C-166006CAS: 132203-70-4	- - -	To inquire	Tue 15 Apr 25
Cilnidipine REF: 7W-GP6753CAS: 132203-70-4	- - -	To inquire	Tue 15 Apr 25
Cilnidipine, 99% REF: AC-46175CAS: 132203-70-4	99%	To inquire	Thu 17 Apr 25
Cilnidipine-d3 REF: 4Z-C-166005CAS: 132203-70-4	- - -	To inquire	Mon 21 Apr 25
Cilnidipine RS REF: 2K-1070600021CAS: 132203-70-4	- - -	To inquire	Tue 22 Apr 25
Cilnidipine REF: TR-C441375CAS: 132203-70-4	- - -	94.00 €~699.00 €	Thu 24 Apr 25
Cilnidipine-d3 REF: TR-C441377CAS: 132203-70-4	- - -	352.00 €~2,322.00 €	Thu 24 Apr 25
Cilnidipine - Bio-X ™ REF: 3D-BC164309CAS: 132203-70-4	Min. 95%	147.00 €	Fri 25 Apr 25
Cilnidipine REF: 3D-FC20435CAS: 132203-70-4	Min. 95%	147.00 €~663.00 €	Fri 25 Apr 25