CAS 132203-70-4
:Cilnidipine
Description:
Cilnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists and exhibits a dual mechanism of action by blocking both L-type and N-type calcium channels. This unique property allows cilnidipine to not only reduce vascular resistance and lower blood pressure but also to provide neuroprotective effects by inhibiting neurotransmitter release in the sympathetic nervous system. Cilnidipine is typically administered orally and is known for its long duration of action, which contributes to improved patient compliance. The substance is characterized by its relatively high lipophilicity, which influences its absorption and distribution in the body. Common side effects may include dizziness, flushing, and peripheral edema, similar to other calcium channel blockers. Its pharmacokinetics involve hepatic metabolism, primarily through cytochrome P450 enzymes, and it is excreted mainly via urine. Overall, cilnidipine represents a valuable therapeutic option in managing high blood pressure, particularly in patients who may benefit from its unique pharmacological profile.
Formula:C27H28N2O7
InChI:InChI=1/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChI key:InChIKey=KJEBULYHNRNJTE-DHZHZOJONA-N
SMILES:C(OC/C=C/C1=CC=CC=C1)(=O)C=2C(C(C(OCCOC)=O)=C(C)NC2C)C3=CC(N(=O)=O)=CC=C3
Synonyms:- (+/-)-(E)-Cinnamyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
- (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl acetate
- (±)-Frc 8653
- 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-({[(2E)-3-phenylprop-2-en-1-yl]oxy}methyl)-1,4-dihydropyridine-3-carboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
- Atelec
- Cilacar 10
- Cinaldipine
- Cinalong
- Frg 8653
- See more synonyms
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Cilnidipine
CAS:Formula:C27H28N2O7Purity:>98.0%(HPLC)(qNMR)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:492.53Cilnidipine
CAS:Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.Formula:C27H28N2O7Purity:99.79% - 99.96%Color and Shape:White SolidMolecular weight:492.52043-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:Formula:C27H28N2O7Purity:99%Color and Shape:SolidMolecular weight:492.5204Cilnidipine
CAS:Controlled ProductApplications A dihydropyridine calcium channel blocker.
References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992), Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992), Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993),Formula:C27H28N2O7Color and Shape:NeatMolecular weight:492.52Cilnidipine-d3
CAS:Controlled ProductApplications Isotope labelled Clindipine (C441375), a dihydropyridine calcium channel blocker.
References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992), Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992), Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993Formula:C27D3H25N2O7Color and Shape:NeatMolecular weight:495.539Cilnidipine
CAS:3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylateFormula:C27H28N2O7Purity:99%Molecular weight:492.52Cilnidipine - Bio-X ™
CAS:Clinidipine is a dihydropyridine calcium channel blocker that is used to treat hypertension. This drug acts on L-type calcium channels of blood vessels by blocking calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. . Cilnidipine also shows activity against N-type calcium channels.
Formula:C27H28N2O7Purity:Min. 95%Color and Shape:PowderMolecular weight:492.52 g/molCilnidipine
CAS:Inhibits L- and N-type calcium channels; anti-hypertensive; neuroprotective
Formula:C27H28N2O7Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:492.52 g/mol
