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CAS 132684-60-7

:

fmoc-L-tert-leucine

Description:
Fmoc-L-tert-leucine, with the CAS number 132684-60-7, is a protected form of the amino acid leucine, commonly used in peptide synthesis. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective moiety that allows for selective deprotection during the synthesis process, facilitating the assembly of peptides without interfering with the amino acid's reactivity. This compound features a tert-butyl side chain, which contributes to its hydrophobic characteristics, making it useful in the synthesis of peptides that require stability and solubility in organic solvents. Fmoc-L-tert-leucine is typically white to off-white in appearance and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but less soluble in water. Its stability under standard laboratory conditions makes it a valuable reagent in organic chemistry and biochemistry, particularly in solid-phase peptide synthesis. Additionally, the Fmoc group can be removed under mild basic conditions, allowing for the subsequent coupling of other amino acids to form longer peptide chains.
Formula:C21H23NO4
InChI:InChI=1/C21H23NO4/c1-21(2,3)18(19(23)24)22-20(25)26-12-17-15-10-6-4-8-13(15)14-9-5-7-11-16(14)17/h4-11,17-18H,12H2,1-3H3,(H,22,25)(H,23,24)/t18-/m1/s1
SMILES:CC(C)(C)[C@@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • Fmoc-tBu-Gly-OH
  • Fmoc-Tle-OH
  • NALPHA-9-Fluorenylmethoxycarbonyl-L-tert-leucine
  • N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine
  • Fmoc-L-tert.leucine
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