CAS 132907-72-3

Ramosetron Hydrochloride

Description:

Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used in the management of nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. It is characterized by its ability to block the action of serotonin at these receptors, which play a crucial role in the vomiting reflex. The compound is typically administered orally or intravenously, depending on the clinical scenario. Ramosetron is known for its relatively long half-life, allowing for less frequent dosing compared to some other antiemetics. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. The hydrochloride salt form enhances its solubility and stability, making it suitable for pharmaceutical formulations. Common side effects may include headache, constipation, and dizziness, although it is generally well-tolerated. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications. Overall, Ramosetron Hydrochloride represents an important option in the therapeutic arsenal against nausea and vomiting.

Formula: C₁₇H₁₈ClN₃O

InChI: InChI=1/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChI key: InChIKey=XIXYTCLDXQRHJO-RFVHGSKJSA-N

SMILES: C(=O)(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3CC4=C(CC3)N=CN4.Cl

Synonyms:

• (-)-(R)-5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole monohydrochloride
• (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone hydrochloride (1:1)
• (R)-(-)-Ramosetron hydrochloride
• Irribow
• Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-
• Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride
• Methanone, (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-, hydrochloride (1:1)
• Ramosetron HCl
• Ym 060
• Ramosetron hydrochloride
• Nasea OD
• (r)-monohydrochlorid
• (r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr
• RAMOSETRON HYDROCHLORIDE 98.5% MIN
• ym060
• (R)-YM-060
• (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon
• Ramosetron Hydrochlorid
• (-)-5-(R)-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride
• (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride

Methanone, (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-, hydrochloride (1:1)

CAS: 132907-72-3

Formula: C₁₇H₁₈ClN₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 315.7973

Ref: IN-DA0011DB

Ramosetron hydrochloride

CAS: 132907-72-3

Formula: C₁₇H₁₈ClN₃O

Molecular weight: 315.80

Ref: 7W-GP9905

Ramosetron hydrochloride

CAS: 132907-72-3

Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.

Formula: C₁₇H₁₈ClN₃O

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 315.8

Ref: TM-T4562L

Ramosetron Hydrochloride

Controlled Product

CAS: 132907-72-3

Stability Hygroscopic
Applications Selective serotonin 5HT3, receptor antagonist; structurally different from Ondansetron (O655000), Granisetron (G780000). Antiemetic.
References Miyata, K., et al.: J. Pharmacol. Exp. Ther., 259, 15 (1991), Miura, H., et al.: Biomed. Chromatogr., 8, 103 (1994), Tabata, H., et al.: Arzneim.-Forsch., 45, 760 (1995),

Formula: C₁₇H₁₇N₃O·ClH

Color and Shape: Neat

Molecular weight: 315.80

Ref: TR-R113050

Ramosetron hydrochloride

Controlled Product

CAS: 132907-72-3

5-HT3 serotonin receptor antagonist

Formula: C₁₇H₁₇N₃O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 315.8 g/mol

Ref: 3D-FR27680

Ramosetron Hydrochloride

CAS: 132907-72-3

Formula: C₁₇H₁₇N₃OHCl

Molecular weight: 279.34 : 36.46

Ref: ST-EA-CP-R46002