CymitQuimica logo

CAS 133073-73-1

:

L-amethopterin hydrate

Description:
L-amethopterin hydrate, also known as methotrexate, is a potent antimetabolite and antifolate medication primarily used in the treatment of certain cancers and autoimmune diseases. It functions by inhibiting dihydrofolate reductase, an enzyme critical for DNA synthesis and cell replication, thereby impeding the growth of rapidly dividing cells. This compound is characterized by its crystalline structure and is typically soluble in water, which facilitates its administration in clinical settings. L-amethopterin hydrate exhibits a range of pharmacological effects, including immunosuppressive properties, making it valuable in treating conditions like rheumatoid arthritis and psoriasis. Its use, however, is accompanied by potential side effects, including toxicity to normal rapidly dividing cells, which necessitates careful monitoring during therapy. The compound's chemical stability and solubility profile are essential for its formulation in various dosage forms, including oral tablets and injectable solutions. Overall, L-amethopterin hydrate is a critical agent in oncology and rheumatology, with a well-established role in modern medical practice.
Formula:C20H24N8O6
InChI:InChI=1/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
InChI key:FPJYMUQSRFJSEW-ZOWNYOTGSA-N
SMILES:CN(Cc1cnc2c(c(N)[nH]c(=N)n2)n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O
Found 10 products.