CAS 1332391-11-3

Formula: C20H13F4N5O2S

InChI: InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)

InChI key: BAANHOAPFBHUDX-UHFFFAOYSA-N

SMILES: C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Formula: C₂₀H₁₃F₄N₅O₂S

Purity: 98.6%

Color and Shape: Solid

Molecular weight: 463.408

Ref: TM-T12146

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide

Formula: C₂₀H₁₃F₄N₅O₂S

Purity: ≥95%

Molecular weight: 463.41

Ref: 54-BUP08683

N-Desmethyl Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 463.41

Ref: 4Z-A-284003

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Purity: 98%

Molecular weight: 463.4081

Ref: IN-DA01NV7R

N-Desmethyl Apalutamide

Controlled Product

CAS: 1332391-11-3

Applications N-Desmethyl Apalutamide has been exploresd asthiohydantion androgen receptor antagonist for treament of cancer
References Bignan, G.C. PCT Int. Appl. (2018), WO 2018037342 A1 20180301.

Formula: C₂₀H₁₃F₄N₅O₂S

Color and Shape: Neat

Molecular weight: 463.41

Ref: TR-D291395

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

Formula: C₂₀H₁₃F₄N₅O₂S

Purity: 98%

Molecular weight: 463.41

Ref: IN-DG01289413

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Molecular weight: 463.4

Ref: BE-RMCA245002

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formula: C₂₀H₁₃F₄N₅O₂S

Molecular weight: 463.41

Ref: ST-EA-CP-A92016

N-Desmethyl Apalutamide-d4

Controlled Product

CAS: 1332391-11-3

Formula: C₂₀D₄H₉F₄N₅O₂S

Color and Shape: Neat

Molecular weight: 467.433

Ref: TR-D291398

N-Desmethyl Apalutamide D-13C215N

Controlled Product

CAS: 1332391-11-3

Formula: C₂C₁₈H₁₃F₄₁₅NN₄O₂S

Color and Shape: Neat

Molecular weight: 466.387

Ref: TR-D291397

N-Desmethyl-apalutamide

CAS: 1332391-11-3

Apalutamide is a nonsteroidal antiandrogen that binds to the androgen receptor in prostate cancer cells. It has been shown to inhibit the proliferation of human prostate cancer cell lines and tumor xenografts in nude mice. Apalutamide is a potent inhibitor of protein interactions with the androgen receptor, which may be due to its ability to compete with testosterone for binding sites. It also has an activating effect on the androgen receptor, leading to increased transcription of genes regulated by this receptor.

Formula: C₂₀H₁₃F₄N₅O₂S

Purity: Min. 95%

Molecular weight: 463.4 g/mol

Ref: 3D-HDC39111