CAS 1338190-14-9

F44-A13

Formula: C28H40N4O5S

InChI: InChI=1S/C28H40N4O5S/c1-7-31(8-2)24-14-11-22(19-32(18-21-9-10-21)27(34)30-28(4,5)6)26(17-24)37-38(35,36)25-15-12-23(13-16-25)29-20(3)33/h11-17,21H,7-10,18-19H2,1-6H3,(H,29,33)(H,30,34)

InChI key: ARHQGFNNEONRES-UHFFFAOYSA-N

SMILES: CCN(CC)C1=CC(=C(C=C1)CN(CC2CC2)C(=O)NC(C)(C)C)OS(=O)(=O)C3=CC=C(C=C3)NC(=O)C

Synonyms:

• F44-A13

F44-A13

CAS: 1338190-14-9

F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC₅₀ value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].

Formula: C₂₈H₄₀N₄O₅S

Color and Shape: Solid

Molecular weight: 544.71

Ref: TM-T86396