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CAS 133972-52-8

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BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE)

Description:
Big Endothelin-1 (1-31) is a precursor peptide of the endothelin family, specifically derived from the human and bovine sources. It is a 31-amino acid peptide that plays a crucial role in various physiological processes, particularly in vasoconstriction and blood pressure regulation. Endothelins are known for their potent vasoconstrictive properties and are involved in the pathophysiology of several cardiovascular diseases. The peptide is synthesized in endothelial cells and is released into the bloodstream, where it exerts its effects on vascular smooth muscle cells. Big Endothelin-1 is biologically inactive until it is cleaved by specific enzymes to produce the active forms, endothelin-1, endothelin-2, and endothelin-3. Its structure includes a characteristic disulfide bond that is essential for its stability and biological activity. The CAS number 133972-52-8 uniquely identifies this peptide in chemical databases, facilitating research and applications in pharmacology and biochemistry. Overall, Big Endothelin-1 is significant in understanding vascular biology and developing therapeutic strategies for cardiovascular disorders.
Formula:C162H236N38O47S5
InChI:InChI=1S/C162H236N38O47S5/c1-19-83(15)129(158(242)183-105(59-89-65-168-96-33-25-24-32-94(89)96)143(227)192-125(79(7)8)156(240)184-108(62-120(165)207)145(229)198-131(85(17)204)161(245)200-52-29-35-118(200)153(237)174-99(46-48-122(210)211)134(218)178-107(61-91-67-167-76-170-91)144(228)193-127(81(11)12)157(241)195-128(82(13)14)160(244)199-51-28-36-119(199)154(238)185-111(162(246)247)58-88-39-43-93(206)44-40-88)197-159(243)130(84(16)20-2)196-146(230)110(64-124(214)215)181-138(222)102(55-78(5)6)175-141(225)106(60-90-66-166-75-169-90)179-150(234)115-72-250-249-71-95(164)132(216)186-112(68-201)149(233)191-116-73-251-252-74-117(152(236)194-126(80(9)10)155(239)182-104(57-87-37-41-92(205)42-38-87)139(223)177-103(140(224)190-115)56-86-30-22-21-23-31-86)189-135(219)98(45-47-121(208)209)172-133(217)97(34-26-27-50-163)171-142(226)109(63-123(212)213)180-136(220)100(49-53-248-18)173-137(221)101(54-77(3)4)176-147(231)113(69-202)187-148(232)114(70-203)188-151(116)235/h21-25,30-33,37-44,65-67,75-85,95,97-119,125-131,168,201-206H,19-20,26-29,34-36,45-64,68-74,163-164H2,1-18H3,(H2,165,207)(H,166,169)(H,167,170)(H,171,226)(H,172,217)(H,173,221)(H,174,237)(H,175,225)(H,176,231)(H,177,223)(H,178,218)(H,179,234)(H,180,220)(H,181,222)(H,182,239)(H,183,242)(H,184,240)(H,185,238)(H,186,216)(H,187,232)(H,188,235)(H,189,219)(H,190,224)(H,191,233)(H,192,227)(H,193,228)(H,194,236)(H,195,241)(H,196,230)(H,197,243)(H,198,229)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,246,247)/t83-,84-,85+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,125-,126-,127-,128-,129-,130-,131-/m0/s1
InChI key:JKSRICZEYPPRFI-QPAZCVSESA-N
SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC4=CNC=N4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CNC=N7)NC(=O)[C@@H]8CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H]9CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N8)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC9=O)CO)CO)CC(C)C)CCSC)CC(=O)O)CCCCN)CCC(=O)O)CO)N
Synonyms:
  • Big Et-1 (1-31) (Human, Bovine)
  • Big Et-1 (1-31) (Human, Bovine) Trifluoroacetate Salt
  • Big Endothelin-1 (1-31) (Human, Bovine) Trifluoroacetate Salt
  • Endothelin-1 (1-31) (Human)
  • Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr
  • H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Oh
  • Endothelin 1 (swine), 21a-L-valine-21b-L-asparagine-21c-L-threonine-21d-L-proline-21e-L-glutamic acid-21f-L-histidine-21g-L-valine-21h-L-valine-21i-L-proline-21j-L-tyrosine-
  • BIG ENDOTHELIN-1 (1-31) (HUMAN, BOVINE)
  • Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-OH trifluoroacetate salt (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
  • Big Endothelin-1 (1-31) (huMan, bovine)
  • 1-31-Human big endothelin 1
Found 3 products.