CAS 134308-13-7

Tolcapone

Description:

Tolcapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT), primarily used in the treatment of Parkinson's disease. It enhances the effects of levodopa by preventing the breakdown of dopamine in the brain, thereby improving motor function in patients. The chemical formula of Tolcapone is C14H15N3O5S, and it features a sulfonamide group, which contributes to its pharmacological activity. Tolcapone is characterized by its moderate solubility in water and its ability to cross the blood-brain barrier, making it effective in central nervous system applications. The compound is typically administered orally and is known for its potential side effects, including liver toxicity, which necessitates regular monitoring of liver function in patients. Additionally, it may interact with other medications, so careful consideration of drug interactions is essential in clinical settings. Overall, Tolcapone represents a significant therapeutic option for managing symptoms associated with Parkinson's disease, particularly in patients experiencing fluctuations in response to levodopa therapy.

Formula: C₁₄H₁₁NO₅

InChI: InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3

InChI key: InChIKey=MIQPIUSUKVNLNT-UHFFFAOYSA-N

SMILES: C(=O)(C1=CC(N(=O)=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2

Synonyms:

• (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanon
• (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
• 3,4-Dihydroxy-4'-Methyl-5-Nitrobenzophenone
• 3,4-Dihydroxyl-5-Nitrobenzyl,4'-Methylbenzenyl Ketone
• Methanone, (3,4-Dihydroxy-5-Nitrophenyl)(4-Methylphenyl)-
• Ro 40-7592
• Ro40-7592
• Talcapone
• Tasmar
• Tolcapone

Tolcapone

CAS: 134308-13-7

Formula: C₁₄H₁₁NO₅

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow to Green powder to crystal

Molecular weight: 273.24

Ref: 3B-T3856

Tolcapone

CAS: 134308-13-7

Ketones and quinones, w/not with other oxygen function,and their halogenated,sulfated,nitrated,or nitrosated derivatives, nesoi

Formula: C₁₄H₁₁NO₅

Color and Shape: Yellow Powder

Molecular weight: 273.06372

Ref: 45-1670207

(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone

CAS: 134308-13-7

Formula: C₁₄H₁₁NO₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 273.2408

Ref: IN-DA0038AR

Tolcapone

CAS: 134308-13-7

Formula: C₁₄H₁₁NO₅

Molecular weight: 273.24

Ref: 7W-GP7033

Tolcapone

CAS: 134308-13-7

Formula: C₁₄H₁₁NO₅

Color and Shape: Yellow Solid

Molecular weight: 273.25

Ref: 4Z-T-151

Tolcapone

CAS: 134308-13-7

Tolcapone

Formula: C₁₄H₁₁NO₅

Purity: ≥98%

Molecular weight: 273.24

Ref: 54-BUP15528

Tolcapone

CAS: 134308-13-7

3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone

Formula: C₁₄H₁₁NO₅

Purity: 98%

Molecular weight: 273.24

Ref: IN-DG154334

Tolcapone

Controlled Product

CAS: 134308-13-7

Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.
References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),

Formula: C₁₄H₁₁NO₅

Color and Shape: Neat

Molecular weight: 273.24

Ref: TR-T535250

Tolcapone

Controlled Product

CAS: 134308-13-7

Catechol-O-methyltransferase inhibitor; brain penetrant

Formula: C₁₄H₁₁NO₅

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 273.24 g/mol

Ref: 3D-FT28305

Tolcapone

CAS: 134308-13-7

Ref: BE-RMCT228000

Tolcapone

CAS: 134308-13-7

Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa

Formula: C₁₄H₁₁NO₅

Purity: 98.93% - 99.68%

Color and Shape: Solid

Molecular weight: 273.24

Ref: TM-T6708

Tolcapone - Bio-X ™

Controlled Product

CAS: 134308-13-7

Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that is used as adjunct therapy to manage symptoms of Parkinson’s disease. Although its precise mechanism is unknown, it is thought to be an inhibitor of COMT and allows for a greater reduction in the symptoms of Parkinson’s.

Formula: C₁₄H₁₁NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 273.24 g/mol

Ref: 3D-BT164481

Tolcapone

CAS: 134308-13-7

Formula: C₁₄H₁₁NO₅

Molecular weight: 273.24

Ref: ST-EA-CP-T164000

Tolcapone

CAS: 134308-13-7

Purity: 99%

Molecular weight: 273.064

Ref: 10-F858650