CAS 134523-00-5

Atorvastatin

Description:

Atorvastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its mechanism of action involves the inhibition of HMG-CoA reductase, an enzyme critical in the cholesterol biosynthesis pathway, leading to decreased levels of low-density lipoprotein (LDL) cholesterol and total cholesterol in the bloodstream. Atorvastatin is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its complex structure. The compound is typically administered orally and exhibits good bioavailability. It is metabolized primarily in the liver, with a significant portion undergoing first-pass metabolism. Common side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances. Atorvastatin is often prescribed in conjunction with lifestyle modifications, such as diet and exercise, to enhance its efficacy in lowering cholesterol levels. Its therapeutic benefits, alongside potential risks, necessitate careful monitoring by healthcare professionals during treatment.

Formula: C₃₃H₃₅FN₂O₅

InChI: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1

InChI key: InChIKey=XUKUURHRXDUEBC-KAYWLYCHSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4

Synonyms:

• (3R,5R)-7-[2-(4-Fluorophenyl)-3-Phenyl-4-(Phenylcarbamoyl)-5-Propan-2-Yl-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (3S,5S)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
• (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
• (βR,δR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
• 1H-Pyrrole-1-Heptanoic Acid
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, [R-(R*,R*)]-
• 1H-pyrrole-1-heptanoate, 3-benzoyl-5-(4-fluorophenyl)-β,δ-dihydroxy-2-(1-methylethyl)-4-phenyl-, calcium salt, (betaR,deltaR)- (1:1)
• Atavastatin
• Atofast
• Atorcor
• Atorfit 20
• Atorin
• Atoris
• Atorvastatin Acid
• Atorvox
• Atrox
• Cardyl
• Lipilou
• Lipinon
• Statofilm
• calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Formula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 1,209.41

Ref: 3B-A2476

(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

CAS: 134523-00-5

Formula: C₃₃H₃₅FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 558.6398

Ref: IN-DA00384N

Atorvastatin

CAS: 134523-00-5

Formula: C₃₃H₃₅FN₂O₅

Purity: ≥ 98%

Color and Shape: White to off-white crystalline powder

Molecular weight: 558.64

Ref: 7W-GP7735

Des-(N-Phenyl)Carbamoyl Atorvastatin Calcium Salt

Controlled Product

CAS: 134523-00-5, 2247346-41-2

Formula: (C₂₆H₂₉FNO₄)•Ca

Color and Shape: Neat

Molecular weight: 2(438.52) + (40.08)

Ref: TR-F621870

Atorvastatin acid

CAS: 134523-00-5

Atorvastatin acid is a pharmaceutical compound belonging to the class of statins, which is a synthetic derivative of fungal metabolites. It functions as an HMG-CoA reductase inhibitor, playing a critical role in the cholesterol biosynthesis pathway. By inhibiting this key enzyme, atorvastatin acid effectively reduces the conversion of HMG-CoA to mevalonate, a precursor of cholesterol, thus lowering overall cholesterol levels in the bloodstream.

Formula: C₃₃H₃₅FN₂O₅

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 558.64 g/mol

Ref: 3D-FF59474

Atorvastatin

CAS: 134523-00-5

Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.

Formula: C₃₃H₃₅FN₂O₅

Purity: 99.37% - 99.69%

Color and Shape: Solid

Molecular weight: 558.64

Ref: TM-T20765

(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid

CAS: 134523-00-5

Formula: C₃₃H₃₅FN₂O₅

Purity: 98.0%

Color and Shape: Solid, White powder

Molecular weight: 558.65

Ref: 10-F079255

3-Fluoro Atorvastatin Sodium Salt-d5

Controlled Product

CAS: 134523-00-5

Formula: C₃₃D₅H₂₉FN₂NaO₅

Color and Shape: Neat

Molecular weight: 585.652

Ref: TR-F587917

3-Fluoro Atorvastatin Sodium Salt

Controlled Product

CAS: 134523-00-5

Applications 3-Fluoro Atorvastatin Sodium Salt is an impurity of Atorvastatin (A791750, Ca Salt); a selective, competitive HMG-CoA reductase inhibitor and the only drug in its class specifically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Formula: C₃₃H₃₄FN₂NaO₅

Color and Shape: Neat

Molecular weight: 580.62

Ref: TR-F587915