CAS 1345675-25-3

6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole dihydrochloride

CAS: 1345675-25-3

Formula: C₂₇H₃₇Cl₂N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 522.5070

Ref: IN-DA009CHQ

6-(3-(Pyrrolidin-1-Yl)Propoxy)-2-(4-(3-(Pyrrolidin-1-Yl)Propoxy)Phenyl)Benzo[d]Oxazole Dihydrochloride

CAS: 1345675-25-3

6-(3-(Pyrrolidin-1-Yl)Propoxy)-2-(4-(3-(Pyrrolidin-1-Yl)Propoxy)Phenyl)Benzo[d]Oxazole Dihydrochloride

Purity: 98%

Molecular weight: 522.51g/mol

Ref: 54-OR1026174

E6446 dihydrochloride

CAS: 1345675-25-3

E6446 dihydrochloride

Purity: ≥98%

Molecular weight: 522.51g/mol

Ref: 54-BUP05219

E6446 dihydrochloride

CAS: 1345675-25-3

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Formula: C₂₇H₃₇Cl₂N₃O₃

Purity: 98.44%

Color and Shape: Solid

Molecular weight: 522.51

Ref: TM-T4068

E6446 (dihydrochloride)

CAS: 1345675-25-3

E6446 (dihydrochloride) is a small molecule compound that acts as a selective inhibitor of the mitotic kinesin Eg5, also known as KIF11. This compound is synthetically derived and is typically utilized in laboratory research. Its mode of action involves binding to the motor domain of Eg5, thereby inhibiting its ATPase activity, which is crucial for the Eg5-driven separation of spindle poles during cell mitosis. By selectively targeting Eg5, E6446 effectively disrupts mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cells.

These characteristics make E6446 an important tool in scientific research, particularly in the study of cancer cells and the development of anticancer therapies. Its ability to halt cell division without affecting other kinesins provides researchers with a precise method to investigate the role of mitotic kinesins in cell cycle progression and to screen for potential therapeutic compounds.

Formula: C₂₇H₃₇Cl₂N₃O₃

Purity: Min. 95%

Molecular weight: 522.51 g/mol

Ref: 3D-VDC67525