CAS 134665-72-8

2'-cyano-2'-deoxyarabinofuranosylcytosine

Description:

2'-Cyano-2'-deoxyarabinofuranosylcytosine, also known as cytarabine or Ara-C, is a nucleoside analog with significant implications in medicinal chemistry, particularly in the treatment of certain types of cancer, such as leukemia. This compound features a cyano group at the 2' position of the deoxyribose sugar, which enhances its stability and bioactivity compared to other nucleosides. Its structure includes a cytosine base linked to a modified sugar moiety, which allows it to interfere with DNA synthesis and repair mechanisms in rapidly dividing cells. The presence of the cyano group contributes to its unique pharmacological properties, making it a potent inhibitor of DNA polymerase. As a result, 2'-cyano-2'-deoxyarabinofuranosylcytosine is utilized in chemotherapy regimens, although it may also exhibit cytotoxic effects on healthy cells, leading to various side effects. Understanding its characteristics is crucial for optimizing its therapeutic use and minimizing adverse reactions in clinical settings.

Formula: C₁₀H₁₂N₄O₄ClH

InChI: InChI=1/C10H12N4O4.ClH/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17;/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17);1H/t5-,6+,8-,9+;/m0./s1

Synonyms:

• 2'-Cyano-2'deoxy-1-beta-D-arabinofuranosylcytosine
• 4-Amino-1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone monohydrochloride
• Cndac
• 2(1H)-Pyrimidinone, 4-amino-1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-, monohydrochloride
• 4-amino-1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one hydrochloride
• 2'-Cyano-2'-deoxyarabinofuranosylcytosine
• 1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride
• CNDAC hydrochloride
• DFP-10917 HYDROCHLORIDE; TAS-109 HYDROCHLORIDE;CNDAC;TAS109;TAS 109
• (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile hydrochloride
• TAS 109
• DFP-10917 Hydrochloride
• CNDAC HCl salt
• 2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride
• CNDAC HCl
• TAS109

2'-cyano-2'-deoxyarabinofuranosylcytosine

CAS: 134665-72-8

Formula: C₁₀H₁₃ClN₄O₄

Purity: 99.59%

Molecular weight: 288.6876

Ref: IN-DA00AEJQ

CNDAC hydrochloride

CAS: 134665-72-8

CNDAC hydrochloride

Purity: ≥98%

Molecular weight: 288.69g/mol

Ref: 54-BUP04864

CNDAC hydrochloride

CAS: 134665-72-8

CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.

Formula: C₁₀H₁₃ClN₄O₄

Purity: 99.45%

Color and Shape: Solid

Molecular weight: 288.69

Ref: TM-T13621

Cndac hydrochloride

CAS: 134665-72-8

Cndac hydrochloride is a potential biomarker that inhibits the methyltransferase activity of DNA. It binds to the enzyme and prevents it from transferring a methyl group to the DNA, which is required for the repair mechanism. This drug has been shown to have potent antitumor activity in experimental models. Cndac hydrochloride is also an oral prodrug that consists of a heterocyclic ring with a fatty acid chain attached at one end and an analog at the other end. The analog can be converted to cndac by esterases in the human body. Cndac hydrochloride has been shown to bind to monoclonal antibodies, which are used as research tools for immunological studies.

Formula: C₁₀H₁₃ClN₄O₄

Purity: Min. 95%

Molecular weight: 288.69 g/mol

Ref: 3D-JFA66572