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CAS 134678-17-4

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Lamivudine

Description:
Lamivudine is an antiretroviral medication primarily used in the treatment of HIV/AIDS and chronic hepatitis B infection. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. The chemical formula of Lamivudine is C8H11N3O3S, and it features a thiophenecarboxamide structure, which contributes to its pharmacological activity. Lamivudine is typically administered orally and is well-absorbed in the gastrointestinal tract, with a favorable safety profile. Common side effects may include headache, fatigue, and gastrointestinal disturbances. It is important to note that Lamivudine is often used in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. The substance is classified as a prescription medication and is included in various treatment guidelines for managing HIV and hepatitis B. Its effectiveness and safety have been well-documented in clinical studies, making it a vital component of antiviral therapy.
Formula:C8H11N3O3S
InChI:InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChI key:InChIKey=JTEGQNOMFQHVDC-NKWVEPMBSA-N
SMILES:O=C1N([C@H]2O[C@@H](CO)SC2)C=CC(N)=N1
Synonyms:
  • (-) 2'-Deoxy-3'-thiacytidine
  • (-)-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cystosine
  • (-)-2¢ -Deoxy-3¢ -Thiacytidine
  • (-)-Bch-189
  • (-)Ngpb-21
  • (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
  • (2R-cis)-4-amino-1-
  • 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
  • 2(1H)-Pyrimidinone, 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
  • 2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-,(2R-cis)-
  • See more synonyms
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