CAS 1353552-97-2

N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide

Description:

N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide, with CAS number 1353552-97-2, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides, aromatic rings, and a piperazine moiety. This compound is typically studied for its potential biological activity, particularly in the context of medicinal chemistry, where it may exhibit properties relevant to drug development. The presence of the furo[3,2-d]pyrimidine core suggests potential interactions with biological targets, possibly influencing pathways related to cell signaling or proliferation. Its solubility, stability, and reactivity can vary based on environmental conditions and the presence of other substances. As with many compounds of this nature, understanding its pharmacokinetics, toxicity, and mechanism of action would be crucial for evaluating its therapeutic potential. Further research and characterization would be necessary to fully elucidate its properties and applications in various fields, including pharmaceuticals and biochemistry.

Formula: C₂₆H₂₆N₆O₃

InChI: InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

InChI key: InChIKey=LZMJNVRJMFMYQS-UHFFFAOYSA-N

SMILES: O(C1=C2C(=NC(NC3=CC=C(C=C3)N4CCN(C)CC4)=N1)C=CO2)C5=CC(NC(C=C)=O)=CC=C5

Synonyms:

• N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
• 2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-
• LY 3337641
• Poseltinib
• HM 71224
• Poseltinib (HM-71224

N-(3-((2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

CAS: 1353552-97-2

N-(3-((2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Formula: C₂₆H₂₆N₆O₃

Purity: 99.5%

Molecular weight: 470.53

Ref: 54-OR1074795

Poseltinib

CAS: 1353552-97-2

Poseltinib is an oral, irreversible BTK inhibitor (IC50 1.95 nM) with higher selectivity over BMX, TEC, and TXK, blocking BCR, FcR, and TLR signaling.

Formula: C₂₆H₂₆N₆O₃

Purity: 99.98%

Color and Shape: Yellow Solid

Molecular weight: 470.523

Ref: TM-T4413

N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide

CAS: 1353552-97-2

Formula: C₂₆H₂₆N₆O₃

Purity: %

Color and Shape: Solid

Molecular weight: 470.5230

Ref: IN-DA01LHDR

Poseltinib

CAS: 1353552-97-2

Poseltinib is a tyrosine kinase inhibitor that is used for the treatment of cancer. It binds to the ATP-binding site of the receptor and blocks the binding of ATP, which inhibits protein synthesis. It has shown efficacy in treating bladder cancer, autoimmune diseases, and acute lymphoblastic leukemia. The drug also has been shown to inhibit extracellular matrix (ECM) degradation by inhibiting collagenases, MMPs and other enzymes that are necessary for ECM remodeling. Poseltinib has also been shown to be effective in treating pemphigoid and other skin disorders by reducing inflammation.

Formula: C₂₆H₂₆N₆O₃

Purity: Min. 95%

Molecular weight: 470.5 g/mol

Ref: 3D-DEC55297