CAS 1354545-57-5

Formula: C29H40Cl2N6O6S

InChI: InChI=1S/C28H35ClN6O3.CH4O3S.ClH/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36;1-5(2,3)4;/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34);1H3,(H,2,3,4);1H/t17-,18+,19+,23+,24-;;/m1../s1

InChI key: JMEAVNFZOQOQRX-RMJUCTSQSA-N

SMILES: COC1=C(C=CC2=C1CC[C@H](CC2)N3CCOCC3)NC4=NC=C(C(=N4)N[C@@H]5[C@@H]6C[C@H]([C@@H]5C(=O)N)C=C6)Cl.CS(=O)(=O)O.Cl

(1S,2S,3R,4R)-3-((5-Chloro-2-(((S)-1-methoxy-7-morpholino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide methanesulfonate hydrochloride

CAS: 1354545-57-5

(1S,2S,3R,4R)-3-((5-Chloro-2-(((S)-1-methoxy-7-morpholino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide methanesulfonate hydrochloride

Formula: C₂₉H₄₀Cl₂N₆O₆S

Purity: 98%

Molecular weight: 671.65

Ref: 54-OR1063006

CEP-28122

CAS: 1354545-57-5

CEP-28122 is a potent antitumor agent that inhibits the growth of tumors by inhibiting the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). CEP-28122 is activated by cyclin-dependent kinases to inhibit EGFR. It has been shown to be active in clinical studies for colorectal adenocarcinoma and other cancers. CEP-28122 has a high degree of selectivity for tumor cells, which are characterized by activation of the EGFR tyrosine kinase domain, and low toxicity for normal cells. The pharmacokinetic properties and molecular pathogenesis of this drug have been studied in detail.

Formula: C₂₈H₃₅ClN₆O₃

Purity: Min. 95%

Molecular weight: 539.07 g/mol

Ref: 3D-EEC54557

CEP-28122 mesylate hydrochloride

CAS: 1354545-57-5

CEP-28122 mesylate hydrochloride, a diaminopyrimidine derivative, is a potent, selective, and orally bioavailable ALK inhibitor with an IC₅₀ of 1.9 nM, exhibiting antitumor and good pharmacokinetic activity ^[1].

Formula: C₂₉H₄₀Cl₂N₆O₆S

Molecular weight: 671.635

Ref: TM-T86040