CAS 135459-87-9

Strontium ranelate

Description:

Strontium ranelate is a chemical compound primarily used in the treatment of osteoporosis. It is a strontium salt of ranelic acid, which is a derivative of the amino acid methionine. The compound is characterized by its ability to both stimulate bone formation and inhibit bone resorption, making it unique among osteoporosis treatments. Strontium ranelate is typically administered orally and is known for its relatively good bioavailability. It has a molecular formula that reflects its strontium and ranelate components, contributing to its pharmacological properties. The compound is generally well-tolerated, although it may have some side effects, including gastrointestinal issues. Its mechanism of action involves the modulation of bone metabolism, promoting a balance between bone formation and resorption, which is crucial for maintaining bone density and strength. Due to its specific action on bone tissue, strontium ranelate has been a subject of interest in the field of bone health and osteoporosis management. However, its use may be limited by regulatory guidelines in various countries.

Formula: C₁₂H₁₀N₂O₈S·2Sr

InChI: InChI=1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;

InChI key: InChIKey=WJKLKWHUBHCSFS-UHFFFAOYSA-N

SMILES: N(CC(O)=O)(CC(O)=O)C1=C(C#N)C(CC(O)=O)=C(C(O)=O)S1.[Sr]

Synonyms:

• 3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-, strontium salt (1:2)
• 5-[Bis(Carboxymethyl)Amino]-3-(Carboxymethyl)-4-Cyanothiophene-2-Carboxylic Acid
• 5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt
• 5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt (1:2)
• Bivalos
• Distrontium renelate
• Osseor
• Protelos
• Protos
• Ranelate Strontium
• S 12911
• S 12911-2
• Strometta
• Stroncium Ranelate
• Strontium 5-[Bis(Carboxylatomethyl)Amino]-3-(Carboxylatomethyl)-4-Cyanothiophene-2-Carboxylate Hydrate (2:1:7)

Strontium Ranelate Hydrate

CAS: 135459-87-9, 674773-07-0

Formula: C₁₂H₆N₂O₈SSr₂·xH₂O

Purity: >97.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 513.49 (as Anhydrous)

Ref: 3B-S0938

2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile

CAS: 135459-87-9

Formula: C₁₂H₆N₂O₈SSr₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.4896

Ref: IN-DA00HU5I

Strontium ranelate

CAS: 135459-87-9

Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis and can slow the course of osteoarthritis of the knee.

Formula: C₁₂H₆N₂O₈S·2Sr

Purity: 98.97%

Color and Shape: Crystalline Solid

Molecular weight: 513.49

Ref: TM-T1641

Strontium ranelate

CAS: 135459-87-9

Formula: C₁₂H₆N₂O₈SSr₂

Molecular weight: 513.49

Ref: 7W-GP2148

Strontium Ranelate

CAS: 135459-87-9

Formula: C₁₂H₆N₂O₈S·2Sr

Color and Shape: White To Off-White Solid

Molecular weight: 338.25 2 87.62

Ref: 4Z-R-164

2,2’-((5-Carboxy-4-(Carboxymethyl)-3-Cyanothiophen-2-Yl)Azanediyl)Diacetic Acid, Distrontium Salt

CAS: 135459-87-9

2,2’-((5-Carboxy-4-(Carboxymethyl)-3-Cyanothiophen-2-Yl)Azanediyl)Diacetic Acid, Distrontium Salt

Purity: 98%

Molecular weight: 513.49g/mol

Ref: 54-OR1009893

Strontium ranelate

CAS: 135459-87-9

Strontium ranelate

Purity: ≥98%

Molecular weight: 513.49g/mol

Ref: 54-BUP14192

Strontium Ranelate

CAS: 135459-87-9

Color and Shape: Neat

Ref: 86-MM3759.00

Strontium Ranelate

Controlled Product

CAS: 135459-87-9

Applications Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.
References Buehler, J., et al.: Bone, 29, 176 (2001), Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001), Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),

Formula: C₁₂H₆N₂O₈S·2Sr

Color and Shape: Neat

Molecular weight: 513.49

Ref: TR-S687700

Strontium ranelate

CAS: 135459-87-9

Strontium ranelate is a strontium salt that is used to treat osteoporosis. It is approved for use in postmenopausal women who are at high risk of fracture. Strontium ranelate has been shown to be effective in vitro and in vivo, as well as in humans. The drug binds to the cation channel TRPV6 and inhibits calcium influx into the cell, thereby reducing bone resorption by osteoclasts. Strontium ranelate also increases the synthesis of new bone by stimulating the production of collagenase and insulin-like growth factor-1. This drug can cause skin reactions such as toxic epidermal necrolysis and erythema multiforme, but these adverse effects are rare.

Formula: C₁₂H₆N₂O₈SSr₂

Purity: Min. 95%

Molecular weight: 513.49 g/mol

Ref: 3D-FS27882

Strontium 2,2′-((5-carboxylato-4-(carboxylatomethyl)-3-cyanothiophen-2-yl)azanediyl)diacetate

CAS: 135459-87-9

Formula: C₁₂H₁₀N₂O₈SSr₂

Purity: ≥98.0%

Color and Shape: White – Slightly pale yellow powder

Molecular weight: 517.52

Ref: 10-F079416