CAS 13553-79-2
:Rifamycin S
Description:
Rifamycin S is a natural antibiotic belonging to the rifamycin class, primarily derived from the bacterium Amycolatopsis rifamycinica. It is characterized by its complex macrocyclic structure, which includes a naphthalenic core and a characteristic rifamycin chromophore. This compound exhibits potent antibacterial activity, particularly against Mycobacterium tuberculosis, making it significant in the treatment of tuberculosis and other bacterial infections. Rifamycin S functions by inhibiting bacterial RNA synthesis through binding to the DNA-dependent RNA polymerase, thereby preventing transcription. The substance is typically administered in its derivative forms, such as rifampicin, which enhances its pharmacological properties. In addition to its antimicrobial efficacy, Rifamycin S has a relatively low toxicity profile, although it can cause side effects such as liver enzyme elevation and hypersensitivity reactions in some patients. Its solubility characteristics vary, influencing its formulation and delivery methods in clinical settings. Overall, Rifamycin S is a crucial compound in the field of antimicrobial therapy, particularly for resistant bacterial strains.
Formula:C37H45NO12
InChI:InChI=1/C37H45NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,41-43H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
InChI key:InChIKey=BTVYFIMKUHNOBZ-ODRIEIDWSA-N
SMILES:O=C1C=2C3=C4C(=O)C(=CC3=O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O
Synonyms:- (14E,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
- (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,9,11-tetraoxo-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
- 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
- 5,17,19-Trihydroxy-23-Methoxy-2,4,12,16,18,20,22-Heptamethyl-1,6,9,11-Tetraoxo-1,2,6,9-Tetrahydro-2,7-(Epoxypentadeca[1,11,13]Trienoimino)Naphtho[2,1-B]Furan-21-Yl Acetate
- Brn 0604802
- Nci 144-130
- Nsc 144130
- Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-
- Rifomycin S
- Unii-Pi53N820Jv
- RIFAMYCIN S
- Rifamycin S CRS
- rifamycin
- RIFAMPICIN S
- 2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,6,9,11(2h)-tetron
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate (7CI,8CI)
- Rifamycin Impurity 2(Rifamycin EP Impurity B)（Rifamycin S)
- Rifaximin impurity E (EP)
- Rifaximin EP Impurity E (Rifamycin S)
- Rifamycin EP Impurity B
- 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-aceta
- 100722
- rifomycins
- nci144-130
- 5,17,19,21-Tetrahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-2,7-(epoxypentadeca[1,11,13]trieniMino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone 21-Acetate
- Rifamycin S USP/EP/BP
- Rifaximin Impurity 5 (Rifaximin EP Impurity E)
- 4-dideoxy-1,4-dihydro-1,4-dioxo-rifamycin
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 13 products.
Rifamycin S
CAS:Formula:C37H45NO12Purity:>98.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:695.76Rifamycin, 1,4-dideoxy-1,4-dihydro-1,4-dioxo-
CAS:Formula:C37H45NO12Purity:97%Color and Shape:SolidMolecular weight:695.7527Rifaximin EP Impurity E (Rifamycin S)
CAS:Formula:C37H45NO12Color and Shape:Orange SolidMolecular weight:695.76Rifamycin S
CAS:Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteriaFormula:C37H45NO12Purity:98.74%Color and Shape:Yellow SolidMolecular weight:695.75Rifamycin S
CAS:Controlled ProductImpurity Rifaximin EP Impurity E
Applications Rifamycin S (Rifaximin EP Impurity E) is a semi-synthetic antibiotic.
References Li, J., et al.: Bioorg. Med. Chem. Lett., 17, 5510 (2007), Patil, R., et al.: J. Pure & App. Microbiol., 2, 211 (2008),Formula:C37H45NO12Color and Shape:NeatMolecular weight:695.75Rifamycin S
CAS:Rifamycin S is a rifamycin that is used as a model system to study the activity of other drugs. It is also used to treat infectious diseases, such as bowel disease, by inhibiting bacterial growth. Rifamycin S has been shown to have drug interactions with other drugs and can cause acute toxicities in the form of multivariate logistic regression. It has also been shown to inhibit the enzymatic inactivation of a number of antibiotics, such as methicillin and penicillin, which may be due to its ability to bind DNA templates. Rifamycin S has also been shown to have antibacterial effects against some bacteria, including Mycobacterium tuberculosis and Mycobacterium avium.Formula:C37H45NO12Purity:Min. 96 Area-%Color and Shape:PowderMolecular weight:695.75 g/mol
