CAS 1359416-20-8
:Formula:C23H25ClN4O3S
InChI:InChI=1S/C23H25ClN4O3S/c1-17(29)28(19-9-4-3-5-10-19)15-22-20-14-27(13-12-23(20)26(2)25-22)32(30,31)16-18-8-6-7-11-21(18)24/h3-11H,12-16H2,1-2H3
InChI key:ACFJCDVCHAVTDF-UHFFFAOYSA-N
SMILES:CC(=O)N(CC1=NN(C2=C1CN(CC2)S(=O)(=O)CC3=CC=CC=C3Cl)C)C4=CC=CC=C4
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P2L-003
CAS:P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.Formula:C23H25ClN4O3SMolecular weight:472.99
