CAS 13647-35-3: Trilostane
Description:Trilostane is a synthetic organic compound primarily used as a pharmaceutical agent in the treatment of conditions related to excess cortisol production, such as Cushing's syndrome. It functions as a competitive inhibitor of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a crucial role in steroidogenesis, thereby reducing cortisol synthesis in the adrenal glands. Trilostane is typically administered orally and is known for its ability to lower cortisol levels effectively. The compound is characterized by its white to off-white crystalline powder form and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water. Its chemical structure includes a steroid-like framework, which is essential for its biological activity. While generally well-tolerated, potential side effects may include gastrointestinal disturbances, fatigue, and hormonal imbalances. Due to its mechanism of action, trilostane is also being investigated for other therapeutic applications related to hormonal regulation. As with any medication, it is important to use trilostane under medical supervision to monitor for efficacy and adverse effects.
Formula:C20H27NO3
InChI:InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChI key:InChIKey=KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES:N#CC1=C(O)C2OC32CCC4C5CCC(O)C5(C)CCC4C3(C)C1
- Synonyms:
- (4Alpha,5Alpha,17Beta)-3,17-Dihydroxy-4,5-Epoxyandrost-2-Ene-2-Carbonitrile
- (4α,5α,17β)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
- 17-Hydroxy-3-Oxo-4,5-Epoxyandrostane-2-Carbonitrile
- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
- Desopan
- Modrastane
- Modrefen
- Modrenal
- Vetoryl
- Win 24540
- See more synonyms
- Trilostane
