CAS 13647-35-3
:Trilostane
Description:
Trilostane is a synthetic organic compound primarily used as a pharmaceutical agent in the treatment of conditions related to excess cortisol production, such as Cushing's syndrome. It functions as a competitive inhibitor of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a crucial role in steroidogenesis, thereby reducing cortisol synthesis in the adrenal glands. Trilostane is typically administered orally and is known for its ability to lower cortisol levels effectively. The compound is characterized by its white to off-white crystalline powder form and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water. Its chemical structure includes a steroid-like framework, which is essential for its biological activity. While generally well-tolerated, potential side effects may include gastrointestinal disturbances, fatigue, and hormonal imbalances. Due to its mechanism of action, trilostane is also being investigated for other therapeutic applications related to hormonal regulation. As with any medication, it is important to use trilostane under medical supervision to monitor for efficacy and adverse effects.
Formula:C20H27NO3
InChI:InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChI key:InChIKey=KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES:C[C@@]12[C@]3([C@](O3)(C(O)=C(C#N)C1)[H])CC[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@H]5O)[H])[H])[H]
Synonyms:- (4Alpha,5Alpha,17Beta)-3,17-Dihydroxy-4,5-Epoxyandrost-2-Ene-2-Carbonitrile
- (4α,5α,17β)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
- 17-Hydroxy-3-Oxo-4,5-Epoxyandrostane-2-Carbonitrile
- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
- Desopan
- Modrastane
- Modrefen
- Modrenal
- Vetoryl
- Win 24540
- Trilostane
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 14 products.
Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
CAS:Formula:C20H27NO3Purity:99%Color and Shape:SolidMolecular weight:329.4333Trilostane
CAS:Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.Formula:C20H27NO3Purity:99.46% - >99.99%Color and Shape:Tan CrystalsMolecular weight:329.43Trilostane
CAS:Formula:C20H27NO3Purity:98.0 - 102.0 % (dried substance)Color and Shape:White or off-white powderMolecular weight:329.43Trilostane (Mixture of Tautomeric Isomers)
CAS:Formula:C20H27NO3Color and Shape:White To Off-White SolidMolecular weight:329.44Trilostane
CAS:Formula:C20H27NO3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:329.44Trilostane
CAS:Controlled Product<p>Applications An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer.<br>References Komanicky, P., et al.: J. Clin. Endocrinol. Metab., 47, 1042 (1978), Mori, Y., et al., Chem. Pharm. Bull., 29, 2646 (1981), Williams, C.J., et al.: Cancer Treat. Rep., 71, 1197 (1987)<br></p>Formula:C20H27NO3Color and Shape:WhiteMolecular weight:329.43Trilostane - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C20H27NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:329.43 g/molTrilostane
CAS:Controlled Product<p>Inhibitor of 3β-hydroxysteroid dehydrogenase in steroid biosynthesis</p>Formula:C20H27NO3Purity:Min. 95%Color and Shape:White PowderMolecular weight:329.43 g/mol
