CAS 1365970-03-1

Glecaprevir

Description:

Glecaprevir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It is classified as a direct-acting antiviral (DAA) and functions as a protease inhibitor, specifically targeting the NS3/4A protease enzyme, which is crucial for viral replication. Glecaprevir is often combined with another antiviral agent, pibrentasvir, to enhance its efficacy and broaden the antiviral spectrum. The substance is characterized by its relatively high potency against various HCV genotypes and is administered orally. In terms of its chemical structure, glecaprevir features a complex arrangement of functional groups that contribute to its biological activity and pharmacokinetic properties. It is generally well-tolerated, with a side effect profile that may include fatigue, headache, and gastrointestinal disturbances. Glecaprevir's development represents a significant advancement in hepatitis C treatment, allowing for shorter treatment durations and improved cure rates compared to previous therapies.

Synonyms:

• Abt-493
• (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35

(1R,2R)-N-[[[(1R,2R)-2-[[4,4-difluoro-4-(3-hydroxy-2-quinoxalinyl)-2-buten-1-yl]oxy]cyclopentyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-2-(difluoromethyl)-N-[(1-methylcyclopropyl)sulfonyl]-cyclopropanecarboxamide cyclic (1→2)-ether

CAS: 1365970-03-1

Formula: C₃₈H₄₆F₄N₆O₉S

Purity: 98%

Color and Shape: Solid

Molecular weight: 838.8653

Ref: IN-DA01EOG9

Glecaprevir

CAS: 1365970-03-1

Formula: C₃₈H₄₆F₄N₆O₉S

Molecular weight: 838.87

Ref: 4Z-G-194001

Glecaprevir

CAS: 1365970-03-1

Glecaprevir

Purity: ≥98%

Molecular weight: 838.87g/mol

Ref: 54-BUP13076

Glecaprevir-13C-d7

CAS: 1365970-03-1

Formula: C₃₇₁₃CH₃₉D₇F₄N₆O₉S

Molecular weight: 846.91

Ref: 4Z-G-194003

Glecaprevir-13C-d3

CAS: 1365970-03-1

Formula: C₃₇₁₃CH₄₃D₃F₄N₆O₉S

Molecular weight: 842.88

Ref: 4Z-G-194002

Glecaprevir

CAS: 1365970-03-1

Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).

Formula: C₃₈H₄₆F₄N₆O₉S

Purity: 99.16% - 99.69%

Color and Shape: Solid

Molecular weight: 838.87

Ref: TM-T5126

Glecaprevir

Controlled Product

CAS: 1365970-03-1

Applications Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.
References Kwo, P., et. al.: J. Hepatol, 67, 263 (2017)Gane, E., et. al.: N. Engl. J. Med, 377, 1448 (2017)

Formula: C₃₈H₄₆F₄N₆O₉S

Color and Shape: Neat

Molecular weight: 838.86

Ref: TR-G407015

GLECAPREVIR

CAS: 1365970-03-1

Purity: 98%

Molecular weight: 838.8699951

Ref: 10-F836983

Glecaprevir-13C,D3

Controlled Product

CAS: 1365970-03-1

Formula: CC₃₇D₃H₄₃F₄N₆O₉S

Color and Shape: Neat

Molecular weight: 842.876

Ref: TR-G407016