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CAS 1365970-03-1

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Glecaprevir

Description:
Glecaprevir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It is classified as a direct-acting antiviral (DAA) and functions as a protease inhibitor, specifically targeting the NS3/4A protease enzyme, which is crucial for viral replication. Glecaprevir is often combined with another antiviral agent, pibrentasvir, to enhance its efficacy and broaden the antiviral spectrum. The substance is characterized by its relatively high potency against various HCV genotypes and is administered orally. In terms of its chemical structure, glecaprevir features a complex arrangement of functional groups that contribute to its biological activity and pharmacokinetic properties. It is generally well-tolerated, with a side effect profile that may include fatigue, headache, and gastrointestinal disturbances. Glecaprevir's development represents a significant advancement in hepatitis C treatment, allowing for shorter treatment durations and improved cure rates compared to previous therapies.
Synonyms:
  • Abt-493
  • (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl)sulfonyl)carbamoyl)cyclopropyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35
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