CAS 136676-91-0

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

Description:

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt, with CAS number 136676-91-0, is a complex organic compound characterized by its unique imidazopyridine structure, which incorporates a tetrahydro framework. This substance features a carboxylic acid functional group, contributing to its acidic properties, and is further modified by the presence of a dimethylamino group and diphenylacetyl moiety, which may influence its pharmacological activity. The trifluoroacetate salt form suggests enhanced solubility and stability, making it suitable for various applications, particularly in medicinal chemistry. The compound's chirality, indicated by the S-(+) designation, implies that it may exhibit specific biological activity, potentially affecting its interaction with biological targets. Overall, this compound's intricate structure and functional groups suggest potential utility in drug development, particularly in the context of neuropharmacology or as a therapeutic agent.

Formula: C₃₁H₃₂N₄O₃₂C₂HF₃O₂

Synonyms:

• PD 123,319 hydrate di(trifluoroacetate) salt

1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-, 2,2,2-trifluoroacetate (1:2)

CAS: 136676-91-0

Formula: C₃₅H₃₄F₆N₄O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 736.6575

Ref: IN-DA001274

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

CAS: 136676-91-0

(S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2)

Purity: 99%

Molecular weight: 736.67g/mol

Ref: 54-PC1006303

PD 123319 ditrifluoroacetate

CAS: 136676-91-0

PD 123319 ditrifluoroacetate is a selective non-peptide AT2 receptor antagonist with IC50 of 34 nM.

Formula: C₃₅H₃₄F₆N₄O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 736.66

Ref: TM-T12381

PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate

Controlled Product

CAS: 130663-39-7, 136676-91-0

Applications A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
References Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);

Formula: C₃₁H₃₂N₄O₃·2C₂HF₃O₂·xH₂O

Color and Shape: Neat

Molecular weight: 736.66 (anhydrous salt)

Ref: TR-P217475

PD 123,319 di(trifluoroacetate) salt hydrate

CAS: 136676-91-0

PD 123,319 di(trifluoroacetate) salt hydrate is a selective inhibitor of the neurokinin-1 receptor. In animal studies, PD 123,319 di(trifluoroacetate) salt hydrate has been shown to reduce hyperactivity and produce an antinociceptive effect by inhibiting the release of substance P from nerve terminals. The compound also has a protective effect on neurons and tissues in animals with traumatic brain injury. It also inhibits spontaneous pain behaviour in rats with cancer or experimental arthritis and reduces angiotensin-II induced hypertension in rats. br>br> PD 123,319 di(trifluoroacetate) salt hydrate binds to the neurokinin-1 receptor (NK1R). The NK1R is a G protein coupled receptor that is expressed on nociceptive neurons in the spinal cord and brainstem. NK1R activation induces the release of substance P from nerve terminals. Substance

Formula: C₃₁H₃₂N₄O₃•(C₂HF₃O₂)₂•(H₂O)x

Purity: Min. 95%

Molecular weight: 736.66 g/mol

Ref: 3D-LFA67691