CAS 136790-76-6

(11α)-16,16-Difluoro-11-hydroxy-9,15-dioxoprostan-1-oic acid

Description:

(11α)-16,16-Difluoro-11-hydroxy-9,15-dioxoprostan-1-oic acid, with CAS number 136790-76-6, is a synthetic compound that belongs to the class of prostaglandin analogs. This substance is characterized by the presence of two fluorine atoms at the 16 position, a hydroxyl group at the 11 position, and a dioxo functional group at the 9 and 15 positions of the prostanoic acid structure. These modifications contribute to its unique biological activity, which may include anti-inflammatory and analgesic properties. The compound's structural features suggest it may interact with specific receptors in the body, potentially influencing various physiological processes. Its solubility, stability, and reactivity can vary based on the functional groups present, making it important for applications in pharmaceutical research and development. As with many synthetic compounds, safety and handling precautions are essential due to potential biological effects and toxicity. Further studies are often required to fully elucidate its pharmacological profile and therapeutic potential.

Formula: C₂₀H₃₂F₂O₅

InChI: InChI=1S/C20H32F2O5/c1-2-3-12-20(21,22)18(25)11-10-15-14(16(23)13-17(15)24)8-6-4-5-7-9-19(26)27/h14-15,17,24H,2-13H2,1H3,(H,26,27)/t14-,15-,17-/m1/s1

InChI key: InChIKey=DBVFKLAGQHYVGQ-BFYDXBDKSA-N

SMILES: C(CC(C(CCCC)(F)F)=O)[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]1O

Synonyms:

• RU 0211
• Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α)-
• Lubiprostone
• (11α)-16,16-Difluoro-11-hydroxy-9,15-dioxoprostan-1-oic acid

Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α)-

CAS: 136790-76-6

Formula: C₂₀H₃₂F₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.4619

Ref: IN-DA0012D8

Lubiprostone

CAS: 136790-76-6

Lubiprostone

Purity: 98%

Molecular weight: 390.46g/mol

Ref: 54-PC108499

Lubiprostone

CAS: 136790-76-6

Lubiprostone

Purity: ≥95%

Molecular weight: 390.46g/mol

Ref: 54-BUP10123

Lubiprostone-d7 (Mixture of Tautomeric Isomers)

CAS: 136790-76-6, 333963-40-9

Formula: C₂₀H₂₅D₇F₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 397.51

Ref: 4Z-L-216

Lubiprostone

CAS: 136790-76-6

Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.

Formula: C₂₀H₃₂F₂O₅

Purity: 97.31% - 98.54%

Color and Shape: White Odorless Crystals Or Crystalline Powder

Molecular weight: 390.46

Ref: TM-T6307

Lubiprostone

Controlled Product

CAS: 136790-76-6

Formula: C₂₀H₃₂F₂O₅

Color and Shape: Neat

Molecular weight: 390.46

Ref: TR-L473500

Lubiprostone

CAS: 136790-76-6

Formula: C₂₀H₃₂F₂O₅

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 390.47

Ref: 3B-L0355

Lubiprostone (ring open)

CAS: 136790-76-6

Lubiprostone is a drug that has been approved in the United States for the treatment of irritable bowel syndrome with constipation. It is a synthetic analog of prostaglandin E1 (PGE1) that acts to increase natural fluid secretion into the bowel by activating ClC-2 chloride channels on the apical surface of intestinal cells. Lubiprostone also increases mitochondrial membrane potential and inhibits atherosclerotic lesion formation. In a clinical trial, patients were randomly assigned to receive either lubiprostone or placebo for six weeks. The lubiprostone group had significant improvement in their symptoms and quality of life compared to those who received placebo. Results from this study suggest that lubiprostone may be an effective treatment for patients with bowel disease.

Formula: C₂₀H₃₂F₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 390.46 g/mol

Ref: 3D-FL24955

7-((1R,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid

CAS: 136790-76-6

Purity: ≥98%

Molecular weight: 390.4679871

Ref: 10-F868928

Lubiprostone Related Compound 8

CAS: 136790-76-6, 333963-40-9

Formula: C₂₀H₃₂F₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 390.47

Ref: 4Z-L-2114