CAS 137234-62-9
:Voriconazole
Description:
Voriconazole is an antifungal medication primarily used to treat serious fungal infections, particularly those caused by Aspergillus species and Candida. It belongs to the triazole class of antifungals, which function by inhibiting the enzyme lanosterol 14α-demethylase, crucial for ergosterol synthesis in fungal cell membranes. Voriconazole is characterized by its broad-spectrum activity against various fungi, making it effective in both invasive and non-invasive infections. The compound is typically administered orally or intravenously and is known for its good bioavailability and tissue penetration. Its pharmacokinetics can be influenced by factors such as age, liver function, and concurrent medications, necessitating careful monitoring of drug levels in some patients. Voriconazole is also associated with potential side effects, including visual disturbances, hepatotoxicity, and skin reactions. Due to its specific mechanism of action and side effect profile, voriconazole is often reserved for cases where other antifungal treatments are ineffective or inappropriate.
Formula:C16H14F3N5O
InChI:InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3
InChI key:InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N
SMILES:[C@@]([C@@H](C)C=1C(F)=CN=CN1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3
Synonyms:- (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
- (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
- (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
- (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
- 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
- 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-
- 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,S*)]-
- Drg 0301
- G-573
- Uk 109496
- Vfend
- Voriconazol
- (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
- Voriconazole
- UK-10949
- (2R,3S/2S,3R)-3-(5-FLUORO-4-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIA
- (aR,S)-a-(2,4-Difluorophenyl)-5-fluoro--methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
- See more synonyms
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Voriconazole
CAS:Formula:C16H14F3N5OPurity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:349.32VORICONAZOLE CRS
CAS:VORICONAZOLE CRSFormula:C16H14F3N5OColor and Shape:White. Powder.Molecular weight:349.3105Voriconazole
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C16H14F3N5OColor and Shape:White PowderMolecular weight:349.11504Voriconazole
CAS:Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.Formula:C16H14F3N5OPurity:98% - 99.91%Color and Shape:SolidMolecular weight:349.3105Voriconazole
CAS:VoriconazoleFormula:C16H14F3N5OPurity:98%Color and Shape:SolidMolecular weight:349.31Voriconazole-d3
CAS:Formula:C16H11D3F3N5OColor and Shape:White To Off-White SolidMolecular weight:352.34Voriconazole
CAS:Formula:C16H14F3N5OPurity:98.0 - 102.0 %Color and Shape:White to off-white crystalline powderMolecular weight:349.31Voriconazole 2.0 mg/ml in Methanol
CAS:Formula:C16H14F3N5OColor and Shape:Single SolutionMolecular weight:349.31Voriconazole (Standard)
CAS:Voriconazole (Standard) is a reference standard for research and analysis in studies involving Voriconazole. Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.Formula:C16H14F3N5OMolecular weight:349.3105(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS:Formula:C16H14F3N5OPurity:99%Color and Shape:SolidMolecular weight:349.3105Ref: IN-DA0012YZ
10mg20.00€50mg24.00€250mg25.00€100mg28.00€1g47.00€5g110.00€10g167.00€25g279.00€4x25g905.00€Voriconazole Impurity 4
CAS:Formula:C16H13ClF3N5OHClColor and Shape:White To Off-White SolidMolecular weight:383.76 36.46Voriconazole - Bio-X ™
CAS:Voriconazole is a synthetic, lipophilic molecule that is used in the treatment of fungal infections. Voriconazole binds to ergosterol which is the major sterol in the cell wall of fungi and inhibits its synthesis, leading to cell death. This drug binds to the enzyme 14α-demethylase allowing the conversion of lanosterol into ergosterol. As a result, this binding leads to the inhibition of ergosterol synthesis, as well as other sterols that are necessary for fungal growth (e.g., squalene).
Formula:C16H14F3N5OPurity:Min. 95%Color and Shape:PowderMolecular weight:349.31 g/mol
