CAS 1374356-45-2

(s)-g-fitinib

Description:

The chemical substance (S)-g-fitinib, with the CAS number 1374356-45-2, is an enantiomer of gefitinib, a well-known tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC). This compound selectively targets the epidermal growth factor receptor (EGFR), inhibiting its activity and thereby interfering with the signaling pathways that promote tumor growth and proliferation. (S)-g-fitinib exhibits a specific stereochemistry that may influence its pharmacological properties, including its potency, efficacy, and side effect profile compared to its racemic counterpart. The substance is characterized by its molecular structure, which includes a quinazoline core, and it is typically administered in oral form. Its solubility, stability, and bioavailability are critical factors that affect its therapeutic application. As with many targeted therapies, understanding the pharmacokinetics and pharmacodynamics of (S)-g-fitinib is essential for optimizing treatment regimens and improving patient outcomes in oncology.

Formula: C₂₁H₂₂Cl₂FN₅O

Synonyms:

• 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
• CRIZOTINIB CHIRAL IMPURITY
• (S)-CRIZOTINIB
• (s)-g-fitinib
• Crizotinib Impurity 24
• Crizotinib S-Isomer
• 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
• ent-crizotinib
• Crizotinib impurity A
• Crizotinib, (S)-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

CAS: 1374356-45-2

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 450.3367

Ref: IN-DA009YYO

(S)-crizotinib

CAS: 1374356-45-2

(S)-crizotinib

Purity: ≥98%

Molecular weight: 450.34g/mol

Ref: 54-BUP09921

(S)-Crizotinib

CAS: 1374356-45-2

Formula: C₂₁H₂₂Cl₂FN₅O

Molecular weight: 450.34

Ref: 4Z-C-123004

(S)-crizotinib

CAS: 1374356-45-2

(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: 98.52% - 99.47%

Color and Shape: Solid

Molecular weight: 450.34

Ref: TM-T6357

(S)-Crizotinib

Controlled Product

CAS: 1374356-45-2

Applications (S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Huber, K.V.M., et al.: Nature, 508, 222 (2014)

Formula: C₂₁H₂₂Cl₂FN₅O

Color and Shape: Off-White To Light Yellow

Molecular weight: 450.34

Ref: TR-C785005

Crizotinib S-Isomer

CAS: 1374356-45-2

Formula: C₂₁H₂₂Cl₂FN₅O

Molecular weight: 450.3

Ref: ST-EA-CP-C101003