CAS 1374356-45-2
:(s)-g-fitinib
Description:
The chemical substance (S)-g-fitinib, with the CAS number 1374356-45-2, is an enantiomer of gefitinib, a well-known tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC). This compound selectively targets the epidermal growth factor receptor (EGFR), inhibiting its activity and thereby interfering with the signaling pathways that promote tumor growth and proliferation. (S)-g-fitinib exhibits a specific stereochemistry that may influence its pharmacological properties, including its potency, efficacy, and side effect profile compared to its racemic counterpart. The substance is characterized by its molecular structure, which includes a quinazoline core, and it is typically administered in oral form. Its solubility, stability, and bioavailability are critical factors that affect its therapeutic application. As with many targeted therapies, understanding the pharmacokinetics and pharmacodynamics of (S)-g-fitinib is essential for optimizing treatment regimens and improving patient outcomes in oncology.
Formula:C21H22Cl2FN5O
InChI:InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
InChI key:KTEIFNKAUNYNJU-LBPRGKRZSA-N
SMILES:C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Synonyms:- 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
- CRIZOTINIB CHIRAL IMPURITY
- (S)-CRIZOTINIB
- (s)-g-fitinib
- Crizotinib Impurity 24
- Crizotinib S-Isomer
- 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
- ent-crizotinib
- Crizotinib impurity A
- Crizotinib, (S)-
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(S)-Crizotinib
CAS:Controlled ProductApplications (S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Huber, K.V.M., et al.: Nature, 508, 222 (2014)Formula:C21H22Cl2FN5OColor and Shape:NeatMolecular weight:450.34(S)-crizotinib
CAS:(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.Formula:C21H22Cl2FN5OPurity:98.52% - 99.47%Color and Shape:SolidMolecular weight:450.34(S)-Crizotinib
CAS:(S)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amineFormula:C21H22Cl2FN5OPurity:98%Molecular weight:450.342-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
CAS:Purity:98%Molecular weight:450.34
