CAS 1374639-75-4: LEE011 Succinate

Description: LEE011 Succinate, also known by its chemical name as a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6, is a compound that has garnered attention in cancer research. It is primarily studied for its potential therapeutic effects in treating various malignancies, including breast cancer and other tumors characterized by dysregulated cell cycle progression. The succinate form indicates that it is a salt or ester derived from succinic acid, which may enhance its solubility and bioavailability. LEE011 functions by disrupting the phosphorylation of retinoblastoma protein, thereby inhibiting cell cycle progression from the G1 to the S phase, leading to reduced proliferation of cancer cells. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing studies are essential to fully elucidate its mechanism of action, optimal dosing regimens, and potential side effects in patients.

Synonyms:

• 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate
• Ribociclib Succinate

Ribociclib succinate

CAS: 1374639-75-4

Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 …

• Formula: C₂₇H₃₆N₈O₅
• Purity: 99.90%
• Color and Shape: Solid
• Molecular weight: 552.63

Butanedioic acid, compd. with 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1)

CAS: 1374639-75-4

• Formula: C₂₇H₃₆N₈O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 552.6253

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide Succinate

CAS: 1374639-75-4

• Purity: 98%
• Molecular weight: 552.63g/mol

Ribociclib succinate

CAS: 1374639-75-4

• Purity: 99.9%
• Molecular weight: 552.63g/mol

LEE011 Succinate

CAS: 1374639-75-4

Applications LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 …

• Formula: C₂₃H₃₀N₈O·C₄H₆O₄
• Color and Shape: Neat
• Molecular weight: 552.63

LEE011 Succinate

CAS: 1374639-75-4

LEE011 Succinate is a versatile compound that has various applications across different industries. It is …

• Formula: C₂₇H₃₆N₈O₅
• Purity: Min. 95%
• Molecular weight: 552.63 g/mol