CAS 1374639-75-4

LEE011 Succinate

Description:

LEE011 Succinate, also known by its chemical name as a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6, is a compound that has garnered attention in cancer research. It is primarily studied for its potential therapeutic effects in treating various malignancies, including breast cancer and other tumors characterized by dysregulated cell cycle progression. The succinate form indicates that it is a salt or ester derived from succinic acid, which may enhance its solubility and bioavailability. LEE011 functions by disrupting the phosphorylation of retinoblastoma protein, thereby inhibiting cell cycle progression from the G1 to the S phase, leading to reduced proliferation of cancer cells. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing studies are essential to fully elucidate its mechanism of action, optimal dosing regimens, and potential side effects in patients.

Synonyms:

• 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate
• Ribociclib Succinate

Ribociclib succinate

CAS: 1374639-75-4

Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).

Formula: C₂₇H₃₆N₈O₅

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 552.63

Ref: TM-T15732

Butanedioic acid, compd. with 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1)

CAS: 1374639-75-4

Formula: C₂₇H₃₆N₈O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 552.6253

Ref: IN-DA0013AM

Ribociclib succinate

CAS: 1374639-75-4

Ribociclib succinate

Purity: ≥98%

Molecular weight: 552.63g/mol

Ref: 54-BUP15340

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide Succinate

CAS: 1374639-75-4

7-Cyclopentyl-N,N-Dimethyl-2-((5-(Piperazin-1-Yl)Pyridin-2-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide Succinate

Purity: 98%

Molecular weight: 552.63g/mol

Ref: 54-OR1026677

LEE011 Succinate

Controlled Product

CAS: 1374639-75-4

Applications LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
References Kim, S., et al.: Mol. Cancer Ther., 12, PR02 (2013); Rader, J., et al.: Clin. Cancer Res., 19, 6173 (2013)

Formula: C₂₃H₃₀N₈O·C₄H₆O₄

Color and Shape: Neat

Molecular weight: 552.63

Ref: TR-L321000

Ribociclib succinate

CAS: 1374639-75-4

Purity: 98%

Molecular weight: 552.64

Ref: 10-F861773

Ribociclib Succinate

CAS: 1374639-75-4

Formula: C₂₃H₃₀N₈OC₄H₆O₄

Molecular weight: 434.55 : 118.09

Ref: ST-EA-CP-R48010