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CAS 1374639-75-4: LEE011 Succinate

Description:LEE011 Succinate, also known by its chemical name as a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6, is a compound that has garnered attention in cancer research. It is primarily studied for its potential therapeutic effects in treating various malignancies, including breast cancer and other tumors characterized by dysregulated cell cycle progression. The succinate form indicates that it is a salt or ester derived from succinic acid, which may enhance its solubility and bioavailability. LEE011 functions by disrupting the phosphorylation of retinoblastoma protein, thereby inhibiting cell cycle progression from the G1 to the S phase, leading to reduced proliferation of cancer cells. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing studies are essential to fully elucidate its mechanism of action, optimal dosing regimens, and potential side effects in patients.

  • Synonyms:
  • 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate
  • Ribociclib Succinate
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Ribociclib succinate

CAS:1374639-75-4

Ref: TM-T15732

2mg35.00 €
5mg51.00 €
10mg73.00 €
25mg97.00 €
50mg115.00 €
100mg168.00 €
200mg271.00 €
500mg484.00 €
1mL*10mM (DMSO)64.00 €
Estimated delivery in United States, on Thursday 13 Mar 2025
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Ref: IN-DA0013AM

1g126.00 €
5g307.00 €
10g526.00 €
100mg53.00 €
250mg69.00 €
Estimated delivery in United States, on Thursday 13 Mar 2025
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LEE011 Succinate

Controlled Product
CAS:1374639-75-4

Ref: TR-L321000

5mg102.00 €
10mg155.00 €
50mg193.00 €
Estimated delivery in United States, on Tuesday 25 Mar 2025
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LEE011 Succinate

CAS:1374639-75-4

Ref: 3D-ZEC63975

5mgDiscontinuedRequest information
10mgDiscontinuedRequest information
25mgDiscontinuedRequest information
50mgDiscontinuedRequest information
100mgDiscontinuedRequest information
Discontinued product
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