CAS 1376162-36-5

Formula: C16H22Cl3N5

InChI: InChI=1S/C16H19N5.3ClH/c17-16(18)13-6-7-15(19-12-13)21-10-8-20(9-11-21)14-4-2-1-3-5-14;;;/h1-7,12H,8-11H2,(H3,17,18);3*1H

InChI key: URSINTNKQBZAQT-UHFFFAOYSA-N

SMILES: C1CN(CCN1C2=CC=CC=C2)C3=NC=C(C=C3)C(=N)N.Cl.Cl.Cl

C1s-IN-1 trihydrochloride

CAS: 1376162-36-5

C1s-IN-1 trihydrochloride

Purity: 98%

Molecular weight: 389.09

Ref: 10-F568222

C1s-IN-1 (trihydrochloride)

CAS: 1376162-36-5

C1s-IN-1 (trihydrochloride)

Formula: C₁₆H₂₂Cl₃N₅

Purity: 98%

Molecular weight: 390.74

Ref: 54-OR1005505

6-(4-Phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride

CAS: 1376162-36-5

Formula: C₁₆H₂₂Cl₃N₅

Purity: 98%

Molecular weight: 390.74

Ref: IN-DG00979441

6-(4-Phenylpiperazin-1-yl)pyridine-3-carboximidamide trihydrochloride

CAS: 1376162-36-5

Versatile small molecule scaffold

Formula: C₁₆H₂₂Cl₃N₅

Purity: Min. 95%

Molecular weight: 390.7 g/mol

Ref: 3D-BFC16236

C1s-IN-1 trihydrochloride

CAS: 1376162-36-5

C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC₅₀ of 85 μM and prevents activation of the classical pathway, with an IC₅₀ of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.

Formula: C₁₆H₂₂Cl₃N₅

Color and Shape: Solid

Molecular weight: 390.738

Ref: TM-T203458