CAS 138-14-7: Deferoxamine mesylate
Description:Deferoxamine mesylate is a chelating agent primarily used in the treatment of iron overload conditions, such as those resulting from repeated blood transfusions in patients with conditions like thalassemia or sickle cell disease. It is a water-soluble compound that forms stable complexes with ferric ions, facilitating their excretion from the body. The substance is derived from the bacterium *Streptomyces pilosus* and is characterized by its ability to selectively bind iron, thereby reducing its toxicity and preventing organ damage. Deferoxamine mesylate is typically administered via subcutaneous or intravenous routes, and its pharmacokinetics involve rapid distribution and renal excretion. The compound is known for its relatively low toxicity profile, although potential side effects may include allergic reactions, gastrointestinal disturbances, and effects on vision with prolonged use. Its effectiveness in managing iron overload has made it a critical therapeutic agent in hematology and oncology settings.
Formula:C25H48N6O8·CH4O3S
InChI:InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key:InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N
SMILES:O=C(NCCCCCN(O)C(=O)C)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.O=S(=O)(O)C
- Synonyms:
- Ba 33112
- Butanediamide, N<sup>4</sup>-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N<sup>1</sup>-(5-aminopentyl)-N<sup>1</sup>-hydroxy-, methanesulfonate (1:1)
- Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
- DFX mesylate
- Deferoxamine B mesylate
- Deferoxamine Mesilate
- Deferoxamine methanesulfonate
- Deferrioxamine B methanesulfonate
- Deferrioxamine methanesulfonate
- Desferal
- See more synonyms
- Desferal mesylate
- Desferrioxamine B mesylate
- Desferrioxamine B methanesulfonate
- Desferrioxamine mesilate
- Desferrioxamine mesylate
- Desferrioxamine methanesulfonate
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
- N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
- NSC 644468
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
- Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)
- Butanediamide, N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-, methanesulfonate (1:1)
