CAS 138-14-7

Deferoxamine mesylate

Description:

Deferoxamine mesylate is a chelating agent primarily used in the treatment of iron overload conditions, such as those resulting from repeated blood transfusions in patients with conditions like thalassemia or sickle cell disease. It is a water-soluble compound that forms stable complexes with ferric ions, facilitating their excretion from the body. The substance is derived from the bacterium *Streptomyces pilosus* and is characterized by its ability to selectively bind iron, thereby reducing its toxicity and preventing organ damage. Deferoxamine mesylate is typically administered via subcutaneous or intravenous routes, and its pharmacokinetics involve rapid distribution and renal excretion. The compound is known for its relatively low toxicity profile, although potential side effects may include allergic reactions, gastrointestinal disturbances, and effects on vision with prolonged use. Its effectiveness in managing iron overload has made it a critical therapeutic agent in hematology and oncology settings.

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

InChI: InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChI key: InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N

SMILES: S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O

Synonyms:

• Ba 33112
• Butanediamide, N⁴-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxy-, methanesulfonate (1:1)
• Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
• DFX mesylate
• Deferoxamine B mesylate
• Deferoxamine Mesilate
• Deferoxamine methanesulfonate
• Deferrioxamine B methanesulfonate
• Deferrioxamine methanesulfonate
• Desferal
• Desferal mesylate
• Desferrioxamine B mesylate
• Desferrioxamine B methanesulfonate
• Desferrioxamine mesilate
• Desferrioxamine mesylate
• Desferrioxamine methanesulfonate
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
• NSC 644468
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)

Deferoxamine Mesylate

CAS: 138-14-7, 70-51-9

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 656.79

Ref: 3B-D4245

Desferrioxamine mesilate

CAS: 138-14-7

Desferrioxamine mesilate

Formula: C₂₇H₅₆N₆O₁₄S₂

Color and Shape: Off-White

Molecular weight: 752.8953

Ref: 47-987

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

CAS: 138-14-7

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0001937

DEFEROXAMINE MESILATE CRS

CAS: 138-14-7

DEFEROXAMINE MESILATE CRS

Formula: C₂₇H₅₆N₆O₁₄S₂

Molecular weight: 752.8953

Ref: 41-D0160000

Deferoxamine Mesylate

CAS: 138-14-7

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Color and Shape: White Powder

Molecular weight: 656.34148

Ref: 45-1166003

Deferoxamine mesylate

CAS: 138-14-7

Formula: C₂₆H₅₂N₆O₁₁S

Purity: 98%

Color and Shape: Solid

Molecular weight: 656.7897

Ref: IN-DA007ZDX

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.

Formula: C₂₆H₅₂N₆O₁₁S

Purity: 94.68% - 99.8%

Color and Shape: Solid

Molecular weight: 656.79

Ref: TM-T1637

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate

Purity: ≥90%

Molecular weight: 656.79g/mol

Ref: 54-BUP17037

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate

Formula: C₂₅H₄₈N₆O₈·CH₃SO₃H

Purity: By hplc: 99.0% by area (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 656.79g/mol

Ref: 54-BIB6311

Desferrioxamine B mesylate

CAS: 138-14-7

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Purity: ≥ 98.0%

Color and Shape: White to almost white powder

Molecular weight: 656.79

Ref: 7W-GP5073

Deferoxamine Mesilate RS

CAS: 138-14-7

Color and Shape: White Solid Powder

Ref: 2K-1086000021

Deferoxamine Mesylate

Controlled Product

CAS: 138-14-7

Applications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);

Formula: C₂₅H₄₈N₆O₈·CH₄O₃S

Color and Shape: Off-White

Molecular weight: 656.79

Ref: TR-D228980

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011

Formula: C₂₆H₅₂N₆O₁₁S

Purity: Min. 98.0 Area-%

Molecular weight: 656.79 g/mol

Ref: 3D-D-0675

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system. Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.

Formula: C₂₆H₅₂N₆O₁₁S

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 656.79 g/mol

Ref: 3D-FD20885