CAS 1380508-60-0

Formula: C24H21N5O3

InChI: InChI=1S/C24H21N5O3/c1-28-14-20(16-6-4-3-5-7-16)29(2)23(30)19-12-26-24(27-22(19)28)32-18-10-8-17(9-11-18)21-13-25-15-31-21/h3-13,15,20H,14H2,1-2H3

InChI key: AWZRPYZJCCJQIQ-UHFFFAOYSA-N

SMILES: CN1CC(N(C(=O)C2=CN=C(N=C21)OC3=CC=C(C=C3)C4=CN=CO4)C)C5=CC=CC=C5

AZ1136

CAS: 1380508-60-0

AZ1136 is a highly selective γ-secretase modulator (GSM) that reduces the levels of Aβ42 and Aβ40, with IC₅₀ values of 990 and 1400 nM, respectively. It increases the levels of Aβ39 and Aβ37 without affecting Aβ38. AZ1136 is utilized in Alzheimer's disease research.

Formula: C₂₄H₂₁N₅O₃

Molecular weight: 427.46

Ref: TM-T214403