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CAS 1380575-43-8

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LDK378 dihydrochloride

Description:
LDK378 dihydrochloride, also known as Lorlatinib, is a small molecule inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that is characterized by anaplastic lymphoma kinase (ALK) gene rearrangements. This compound functions by selectively inhibiting ALK and ROS1 tyrosine kinases, thereby disrupting the signaling pathways that promote tumor growth and survival. LDK378 dihydrochloride is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective against brain metastases associated with ALK-positive NSCLC. The substance is characterized by its high potency and specificity, which contribute to its therapeutic efficacy. In terms of safety, it may be associated with various side effects, including but not limited to central nervous system effects, gastrointestinal disturbances, and metabolic changes. As with any targeted therapy, monitoring for adverse effects and assessing treatment response are crucial components of patient management. Overall, LDK378 dihydrochloride represents a significant advancement in targeted cancer therapies.
Formula:C28H37Cl2N5O3S
Synonyms:
  • 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine,dihydrochloride
  • Cs-1407
  • W-6134
  • LDK-378 dihydrochloride
  • 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine hydrochloride
  • Ceritinib dihydrochloride
  • 5-Chloro-N2-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-Yl)Phenyl)-N4-(2-(Isopropylsulfonyl)Phenyl)Pyrimidine-2,4-Diamine 2Hcl
  • LDK378 2Hcl
  • 5-chloro-N2-(2-isopropoxy-5-Methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyriMidine-2,4-diaMine hydrochloride
  • 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine hydrochloride (1:2)
  • See more synonyms
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