CAS 138402-11-6

Irbesartan

Description:

Irbesartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension and to protect the kidneys in patients with type 2 diabetes. Its chemical formula is C18H18N4O5, and it features a biphenyl structure with a tetrazole ring, contributing to its pharmacological activity. Irbesartan works by selectively blocking the binding of angiotensin II to its receptor, leading to vasodilation and reduced blood pressure. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. The substance is well-absorbed in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Irbesartan is generally well-tolerated, with common side effects including dizziness, fatigue, and gastrointestinal disturbances. It is contraindicated in pregnancy and should be used cautiously in patients with renal impairment. Overall, Irbesartan is an effective medication for managing hypertension and offers additional renal protective benefits in specific populations.

Formula: C₂₅H₂₈N₆O

InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChI key: InChIKey=YOSHYTLCDANDAN-UHFFFAOYSA-N

SMILES: O=C1C2(N=C(CCCC)N1CC3=CC=C(C=C3)C4=C(C=CC=C4)C=5NN=NN5)CCCC2

Synonyms:

• 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 2-Butyl-3-[2′-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one
• 2-Butyl-3-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]-1,3-Diazaspiro[4.4]Non-1-En-4-One
• 2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
• 2-Butyl-3-[[2′-(tetrazol-5-yl)biphenyl-4-yl]-methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
• 2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
• 2-Butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one
• 2-butyl-3-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
• 3-Butyl-2-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]-2,4-Diazaspiro[4.4]Non-3-En-1-One
• Aprovel
• Avapro
• Bms-186295
• Irbesartan (GMP)
• Irbest
• Irbetan
• Kansartan
• Karvea
• Sabervel
• Sr-47436

Irbesartan

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 428.54

Ref: 3B-I0859

Irbesartan

CAS: 138402-11-6

Color and Shape: Neat

Ref: 61-FOR0862.00

Irbesartan

CAS: 138402-11-6

Irbesartan

Formula: C₂₅H₂₈N₆O

Purity: 99.7%

Color and Shape: Off White Solid

Molecular weight: 428.23246

Ref: 47-1093

IRBESARTAN CRS

CAS: 138402-11-6

IRBESARTAN CRS

Formula: C₂₅H₂₈N₆O

Molecular weight: 428.5294

Ref: 41-Y0001166

Irbesartan

CAS: 138402-11-6

Cardiovascular drugs, nesoi

Formula: C₂₅H₂₈N₆O

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 428.23246

Ref: 45-1347700

1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.5294

Ref: IN-DA0018Q6

Irbesartan

CAS: 138402-11-6

Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.

Formula: C₂₅H₂₈N₆O

Purity: 99.79% - 99.81%

Color and Shape: White Crystalline Powder

Molecular weight: 428.53

Ref: TM-T1615

Irbesartan

CAS: 138402-11-6

Irbesartan

Purity: ≥98%

Molecular weight: 428.53g/mol

Ref: 54-BUP17809

Irbesartan

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Color and Shape: White To Off-White Solid

Molecular weight: 428.54

Ref: 4Z-I-021

3-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-2-Butyl-1,3-Diazaspiro[4.4]Non-1-En-4-One

CAS: 138402-11-6

3-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-2-Butyl-1,3-Diazaspiro[4.4]Non-1-En-4-One

Purity: 98%

Molecular weight: 428.53g/mol

Ref: 54-OR1010617

Irbesartan

Controlled Product

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Color and Shape: Neat

Molecular weight: 428.53

Ref: 86-MM0862.00

Irbesartan

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Color and Shape: Neat

Molecular weight: 428.53

Ref: 04-C14373000

Irbesartan

CAS: 138402-11-6

Formula: C₂₅H₂₈N₆O

Purity: 98.0 - 102.0 % (dry basis)

Color and Shape: White to off-white powder

Molecular weight: 428.53

Ref: 7W-GP0710

Irbesartan

Controlled Product

CAS: 138402-11-6

Applications An angiotensin II type 1 (AII1)-receptor antagonist.
References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997), Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998), Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008), Ren, X., et al.: Pharmacol., 83, 80 (2009),

Formula: C₂₅H₂₈N₆O

Color and Shape: Neat

Molecular weight: 428.53

Ref: TR-I751000

2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[4.4]non-1-en-4-one

CAS: 138402-11-6

Purity: 97.0%

Color and Shape: Solid, White - Almost white powder

Molecular weight: 428.5400085449219

Ref: 10-F036499

Irbesartan

CAS: 138402-11-6

Angiotensin II receptor antagonis

Formula: C₂₅H₂₈N₆O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 428.53 g/mol

Ref: 3D-FI24648

Irbesartan - Bio-X ™

CAS: 138402-11-6

Irbesartan is an angiotensin II receptor antagonist that is used to treat hypertension and congestive heart failure. It is also used to delay the progression of diabetic nephropathy. This drug works to works to relax smooth muscles and lower blood pressure.

Formula: C₂₅H₂₈N₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 428.53 g/mol

Ref: 3D-BI164582