CAS 13860-38-3

1-Methylpseudouridine

Description:

1-Methylpseudouridine is a modified nucleoside that is derived from pseudouridine, which is a naturally occurring nucleoside found in various RNA molecules. This compound features a methyl group attached to the nitrogen atom at the 1-position of the pseudouridine structure, which enhances its stability and influences its biological properties. 1-Methylpseudouridine is known for its role in RNA biology, particularly in the context of tRNA and mRNA modifications, where it can affect the folding, stability, and translation efficiency of RNA. The presence of the methyl group can also impact the interaction of RNA with proteins and other nucleic acids. This compound is of interest in various fields, including molecular biology and therapeutic applications, as it may enhance the efficacy of RNA-based drugs and vaccines. Additionally, its unique structural characteristics make it a valuable tool for studying RNA function and modification. Overall, 1-Methylpseudouridine exemplifies the importance of nucleoside modifications in regulating biological processes.

Formula: C₁₀H₁₄N₂O₆

InChI: InChI=1S/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,8+/m1/s1

InChI key: InChIKey=UVBYMVOUBXYSFV-XUTVFYLZSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(=O)NC(=O)N(C)C2

Synonyms:

• (1S)-1,4-anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol
• 1,4-Anhydro-1-(1-Methyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidin-5-Yl)Pentitol
• 1-Methyl-5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
• 2,4(1H,3H)-Pyrimidinedione, 1-methyl-5-beta-D-ribofuranosyl-
• 2,4(1H,3H)-Pyrimidinedione, 1-methyl-5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 2: PN: WO2017201317 SEQID: 2 claimed DNA
• N¹-Methylpseudouridine
• Nsc 240023
• U 50228
• Uracil, 1-methyl-5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
• Uracil, 1-methyl-5-β-D-ribofuranosyl-
• 1-Methylpseudouridine

1-Methylpseudouridine

CAS: 13860-38-3

Formula: C₁₀H₁₄N₂O₆

Purity: >99.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 258.23

Ref: 3B-M3387

2,4(1H,3H)-Pyrimidinedione, 1-methyl-5-β-D-ribofuranosyl-

CAS: 13860-38-3

Formula: C₁₀H₁₄N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 258.2280

Ref: IN-DA0018UH

N1-Methylpseudouridine

CAS: 13860-38-3

N1-Methylpseudouridine

Purity: ≥98%

Molecular weight: 258.23g/mol

Ref: 54-BUP13635

5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-1-Methylpyrimidine-2,4(1H,3H)-Dione

CAS: 13860-38-3

5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-1-Methylpyrimidine-2,4(1H,3H)-Dione

Purity: 97%

Molecular weight: 258.23g/mol

Ref: 54-OR1025971

N1-Methylpseudouridine

CAS: 13860-38-3

N1-Methylpseudouridine (1-Methylpseudouridine) is a methylpseudouridine and enhances translation through eIF2α-dependent and independent mechanisms by

Formula: C₁₀H₁₄N₂O₆

Purity: 98.95% - 99.88%

Color and Shape: Solid

Molecular weight: 258.23

Ref: TM-T19459

1-Methylpseudouridine

CAS: 13860-38-3

1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).

Formula: C₁₀H₁₄N₂O₆

Purity: Min. 98.0 Area-%

Molecular weight: 258.23 g/mol

Ref: 3D-M-4320

1-Methylpseudouridine

CAS: 13860-38-3

1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).

Formula: C₁₀H₁₄N₂O₆

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 258.23 g/mol

Ref: 3D-NM35520

1-N-ME-PSEUDOURIDINE

CAS: 13860-38-3

Formula: C₁₀H₁₄N₂O₆

Purity: 98%

Molecular weight: 258.23

Ref: 10-F532595

1-Methylpseudouridine

Controlled Product

CAS: 13860-38-3

Formula: C₁₀H₁₄N₂O₆

Color and Shape: White

Molecular weight: 258.228

Ref: TR-M249710