CAS 138977-28-3

CAPSAZEPINE

Description:

Capsazepine is a synthetic compound known for its role as a selective antagonist of the capsaicin receptor, also known as TRPV1 (transient receptor potential vanilloid 1). This receptor is involved in the sensation of pain and heat, making capsaezepine of interest in pain management research. The substance is characterized by its ability to inhibit the effects of capsaicin, the active component in chili peppers that activates TRPV1. Capsazepine has been studied for its potential therapeutic applications in treating pain conditions, including neuropathic pain and inflammatory disorders. In terms of its chemical structure, it features a unique arrangement of functional groups that contribute to its biological activity. Capsazepine is typically administered in research settings, and its pharmacokinetics and safety profile are subjects of ongoing investigation. As with many compounds that interact with biological systems, understanding its mechanism of action and potential side effects is crucial for its development as a therapeutic agent.

Formula: C₁₉H₂₁ClN₂O₂S

InChI: InChI=1/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)

InChI key: InChIKey=DRCMAZOSEIMCHM-UHFFFAOYSA-N

SMILES: C(NCCC1=CC=C(Cl)C=C1)(=S)N2CC=3C(=CC(O)=C(O)C3)CCC2

Synonyms:

• 2H-2-Benzazepine-2-carbothioamide, N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-
• Capsazepine Synthetic Analog Of C
• N-[2-(4-Chlorophenyl)Ethyl]-1,3,4,5-Tetrahydro-7,8-Dihydroxy-2H-2-Benzazepine-2-Carbothioamide
• N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
• N-[2-(Chlorophenyl)Ethyl]-1,3,4,5-Tetrahydro-7,8-Dihydroxy-2H-2-Benzazepine-2-Carbothioamide
• Capsazepine
• 2-[[2-(4-Chlorophenyl)ethylamino]thiocarbonyl]-2,3,4,5-tetrahydro-1H-2-benzazepine-7,8-diol
• Capsazepine,98%
• Capsazepin
• capasazepine
• 7;8-DIHYDROXY-2H-2-BENZAZEPINE-2-CARBOTHIOAMIDE

Capsazepine

CAS: 138977-28-3

Formula: C₁₉H₂₁ClN₂O₂S

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 376.90

Ref: 3B-C3923

Capsazepine, 98+%

CAS: 138977-28-3

A competitive antagonist for capsaicin and resiniferatoxin

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 98+%

Color and Shape: Powder, Pale cream to cream

Molecular weight: 376.90

Ref: 02-J63055

Capsazepine

CAS: 138977-28-3

Capsazepine

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 0.98

Molecular weight: 376.9

Ref: 54-OR1022963

Capsazepine

CAS: 138977-28-3

Capsazepine

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 376.9

Ref: 54-BUP06397

Capsazepine

CAS: 138977-28-3

Formula: C₁₉H₂₁ClN₂O₂S

Purity: ≥ 98.5%

Color and Shape: White crystalline powder

Molecular weight: 376.90

Ref: 7W-GP3210

Capsazepine

CAS: 138977-28-3

Formula: C₁₉H₂₁ClN₂O₂S

Molecular weight: 376.90

Ref: 4Z-C-184001

Capsazepine

CAS: 138977-28-3

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.9002

Ref: IN-DA0019YW

Capsazepine

CAS: 138977-28-3

Capsazepine, a TRPV1 antagonist (IC50: 562 nM), blocks capsaicin-induced heat pain.

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 98% - 99.78%

Color and Shape: White Solid

Molecular weight: 376.90

Ref: TM-T7177

N-(4-Chlorophenethyl)-7,8-dihydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide

CAS: 138977-28-3

N-(4-Chlorophenethyl)-7,8-dihydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 98%

Molecular weight: 376.9

Ref: IN-DG119877

Capsazepine

CAS: 138977-28-3

Formula: C₁₉H₂₁ClN₂O₂S

Molecular weight: 376.9

Ref: BE-RMCC054000

Capsazepine

CAS: 138977-28-3

M01458 - Capsazepine

Formula: C₁₉H₂₁ClN₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.9

Ref: 10-M01458

Capsazepine

Controlled Product

CAS: 138977-28-3

Applications A selective vanilloid receptor antagonist (Ki=3.2uM)
References Dickenson and Dray: Br. J. Pharmacol., 104, 1045 (1991), Kwak, et al.: Neuroscience, 86, 619 (1998), Szallasi and Blumberg: Pharmacol. Rev., 51, 159 (999)

Formula: C₁₉H₂₁ClN₂O₂S

Color and Shape: Neat

Molecular weight: 376.9

Ref: TR-C175710