CAS 1391063-17-4

4-((3,5-dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

Description:

The chemical substance known as "4-((3,5-dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile," with the CAS number 1391063-17-4, is a synthetic organic compound characterized by its complex molecular structure, which includes a quinoline core. This compound features multiple functional groups, including an amino group, methoxy groups, and a carbonitrile moiety, contributing to its potential biological activity. The presence of chlorine substituents on the aromatic ring may enhance its lipophilicity and influence its interaction with biological targets. The piperazine moiety suggests possible applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting various diseases. Its structural complexity indicates potential for diverse interactions within biological systems, making it a candidate for further research in drug development. Overall, this compound exemplifies the intricate design often found in modern medicinal chemistry, where modifications to core structures can lead to significant variations in pharmacological properties.

PF-06651481-00

CAS: 1391063-17-4

PF-06651481-00

Purity: ≥95%

Molecular weight: 530.45g/mol

Ref: 54-BUP21345

Bosutinib Impurity 32

CAS: 1391063-17-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Color and Shape: Yellow Solid

Molecular weight: 530.45

Ref: 4Z-B-6436

4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

Controlled Product

CAS: 1391063-17-4

Applications Kinase inhibitors, such as bosutinib, are useful cancer drugs but their target specificity is not fully understood. 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile has been employed as a clinical kinase inhibitor bosutinib to elucidate the recognition mechanism between the ATP-binding site and the compound.
References Levinson, N. M. and Boxer, S. G., Nat Chem. Biol 10, 127 (2014); Yen, T. and Beeharry, N., PCT Int. Appl. WO 2013187967 A1 20131219 (2013);

Formula: C₂₆H₂₉Cl₂N₅O₃

Color and Shape: Neat

Molecular weight: 530.45

Ref: TR-D435380

PF-06651481-00

CAS: 1391063-17-4

PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: 97.01%

Color and Shape: Solid

Molecular weight: 530.45

Ref: TM-T28374

Bosutinib Regio Isomer Impurity

CAS: 1391063-17-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Molecular weight: 530.45

Ref: ST-EA-CP-B80010