CAS 139308-65-9

Tolafentrine

Description:

Tolafentrine is a synthetic chemical compound primarily used as an insecticide in agricultural applications. It belongs to the class of pyrethroids, which are synthetic analogs of natural pyrethrins derived from chrysanthemum flowers. Tolafentrine exhibits a broad spectrum of activity against various pests, including lepidopteran larvae and other insects, making it effective for crop protection. Its mode of action involves disrupting the normal functioning of the insect nervous system, leading to paralysis and death. The compound is characterized by its relatively low toxicity to mammals and birds, which makes it a preferred choice in integrated pest management strategies. Additionally, Tolafentrine is known for its stability and effectiveness under various environmental conditions, although its persistence in the environment can raise concerns regarding potential ecological impacts. As with many pesticides, proper handling and application are essential to minimize risks to non-target organisms and ensure environmental safety.

Formula: C₂₈H₃₁N₃O₄S

InChI: InChI=1/C28H31N3O4S/c1-18-5-11-21(12-6-18)36(32,33)30-20-9-7-19(8-10-20)28-23-16-27(35-4)26(34-3)15-22(23)24-17-31(2)14-13-25(24)29-28/h5-12,15-16,24-25,30H,13-14,17H2,1-4H3/t24-,25-/m0/s1

SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C1=N[C@H]2CCN(C)C[C@H]2c2cc(c(cc12)OC)OC

Synonyms:

• rel-(-)-N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methylbenzenesulfonamide
• N-{4-[(4aS,10bR)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl]phenyl}-4-methylbenzenesulfonamide
• Tolafentrine
• Benzenesulfonamide, N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methyl-, rel-(-)-

Tolafentrine

CAS: 139308-65-9

Formula: C₂₈H₃₁N₃O₄S

Color and Shape: Solid

Molecular weight: 505.6284

Ref: IN-DA001AQ2

Tolafentrine

CAS: 139308-65-9

Formula: C₂₈H₃₁N₃O₄S

Color and Shape: Yellow Solid

Molecular weight: 505.63

Ref: 4Z-T-137001

Tolafentrine

CAS: 139308-65-9

Formula: C₂₈H₃₁N₃O₄S

Ref: TR-TRC-T531000

Tolafentrine

Controlled Product

CAS: 139308-65-9

Applications A dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
References Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),

Formula: C₂₈H₃₁N₃O₄S

Color and Shape: Neat

Molecular weight: 505.63

Ref: TR-T531000

Tolafentrine

CAS: 139308-65-9

Tolafentrine is a drug used to treat chronic bronchitis and inflammatory bowel disease. It is also useful for treating cardiac, chronic pulmonary, and colonic diseases. Tolafentrine has been shown to be effective in clinical trials as a nebulized medication for the treatment of chronic bronchitis. The drug works by inhibiting the release of eosinophil cationic protein from cells in the airway, which reduces inflammation in the lungs. It also inhibits colony-stimulating factor production and reduces systolic pressure. This drug may be useful for cancer treatment by inhibiting angiogenesis (growth of new blood vessels) and inducing apoptosis (cell death). Tolafentrine has been shown to increase thymidine incorporation into DNA and inhibit cell growth in cultured human erythroleukemia cells (THP-1).

Formula: C₂₈H₃₁N₃O₄S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 505.63 g/mol

Ref: 3D-FT28303