CAS 1394837-94-5

EphB4-IN-1

CAS: 1394837-94-5

EphB4-IN-1 is a selective tyrosine kinase inhibitor of EphB4, exhibiting an IC₅₀ value range of 0.16-0.30 μM. It binds to the ATP-binding site of EphB4 in the DFG-in conformation, creating four stable intermolecular hydrogen bonds. Additionally, EphB4-IN-1 inhibits kinases such as Src, Abl1, Lck, and EGFR and prevents the autophosphorylation of EphB4. This compound is applicable in cancer research, including studies on non-small cell lung cancer.

Formula: C₁₈H₁₈N₄O₂

Molecular weight: 322.36

Ref: TM-T217956