CAS 139755-83-2

Sildenafil

Description:

Sildenafil is a pharmaceutical compound primarily known for its use as a treatment for erectile dysfunction and pulmonary arterial hypertension. It functions as a selective inhibitor of phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) and promotes vasodilation in the corpus cavernosum of the penis, facilitating erection in response to sexual stimulation. The molecular formula of sildenafil is C22H30N6O4S, and it has a molecular weight of approximately 474.6 g/mol. The substance is typically administered orally and is available in various formulations, including tablets and oral suspensions. Sildenafil is characterized by its relatively high solubility in water and organic solvents, which aids in its bioavailability. Common side effects may include headaches, flushing, dyspepsia, and visual disturbances. It is important to note that sildenafil should be used under medical supervision, particularly in individuals with cardiovascular conditions or those taking nitrates, due to potential interactions and contraindications.

Formula: C₂₂H₃₀N₆O₄S

InChI: InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChI key: InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(C)CC2)C=C1)C=3NC4=C(C(=O)N3)N(C)N=C4CCC

Synonyms:

• 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
• 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one
• Sildenafil
• Sildenafil Cirtrate
• Piperazine, 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-
• Sildenafil Citrate
• 1H-Pyrazolo[4,3-d]pyrimidine, piperazine deriv.

Sildenafil Citrate

CAS: 139755-83-2, 171599-83-0

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 666.70

Ref: 3B-S0986

Sildenafil

CAS: 139755-83-2

Color and Shape: Neat

Ref: 61-FOR0254.09

Sildenafil 1.0 mg/ml in Methanol

CAS: 139755-83-2

Color and Shape: Single Solution

Ref: 61-AMP0254.09-01

7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-

CAS: 139755-83-2

Formula: C₂₂H₃₀N₆O₄S

Purity: 95%

Color and Shape: Solid

Molecular weight: 474.5764

Ref: IN-DA001BO5

Sildenafil

CAS: 139755-83-2

Formula: C₂₂H₃₀N₆O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 474.58

Ref: 4Z-S-0652

Sildenafil

CAS: 139755-83-2

Color and Shape: Neat

Ref: 86-MM0254.09

Sildenafil

CAS: 139755-83-2

Formula: C₂₂H₃₀N₆O₄S

Color and Shape: Neat

Molecular weight: 474.58

Ref: 04-C16946490

Sildenafil

CAS: 139755-83-2

Purity: 99.90%

Molecular weight: 474.58

Ref: 10-F979721

Sildenafil

CAS: 139755-83-2

Applications Sildenafil is an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996); Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998);

Formula: C₂₂H₃₀N₆O₄S

Color and Shape: Neat

Molecular weight: 474.58

Ref: TR-S435001

Sildenafil - Bio-X ™

CAS: 139755-83-2

Sildenafil is a potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), consequently preventing the degradation of cGMP in the smooth muscle cells of the pulmonary vasculature and penis. For this reason Sildenafil can be used to increase blood flow, decrease inflammation and mucus production in the lungs and also can be used in the treatment of erectile dysfunction in men. This is largely due to the increased availability of cGMP which can cause the relaxation of the smooth muscles to be prolonged.

Formula: C₂₂H₃₀N₆O₄S

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 474.58 g/mol

Ref: 3D-BS164403

Sildenafil

CAS: 139755-83-2

Sildenafil is a pharmaceutical compound, which is a synthetic product derived from chemical processes. It functions as a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). By inhibiting PDE5, sildenafil increases cyclic guanosine monophosphate (cGMP) levels within the smooth muscle cells of the corpus cavernosum. This leads to smooth muscle relaxation and vasodilation, allowing increased blood flow and facilitating penile erection in the presence of sexual stimulation.

Formula: C₂₂H₃₀N₆O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 474.58 g/mol

Ref: 3D-FS27828