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CAS 139755-83-2

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Sildenafil

Description:
Sildenafil is a pharmaceutical compound primarily known for its use as a treatment for erectile dysfunction and pulmonary arterial hypertension. It functions as a selective inhibitor of phosphodiesterase type 5 (PDE5), which leads to increased levels of cyclic guanosine monophosphate (cGMP) and promotes vasodilation in the corpus cavernosum of the penis, facilitating erection in response to sexual stimulation. The molecular formula of sildenafil is C22H30N6O4S, and it has a molecular weight of approximately 474.6 g/mol. The substance is typically administered orally and is available in various formulations, including tablets and oral suspensions. Sildenafil is characterized by its relatively high solubility in water and organic solvents, which aids in its bioavailability. Common side effects may include headaches, flushing, dyspepsia, and visual disturbances. It is important to note that sildenafil should be used under medical supervision, particularly in individuals with cardiovascular conditions or those taking nitrates, due to potential interactions and contraindications.
Formula:C22H30N6O4S
InChI:InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
InChI key:InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N
SMILES:O(CC)C1=C(C=C(S(=O)(=O)N2CCN(C)CC2)C=C1)C=3NC4=C(C(=O)N3)N(C)N=C4CCC
Synonyms:
  • 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
  • 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one
  • Sildenafil
  • Sildenafil Cirtrate
  • Piperazine, 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-
  • Sildenafil Citrate
  • 1H-Pyrazolo[4,3-d]pyrimidine, piperazine deriv.
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Found 13 products.