CAS 13983-13-6

(8E,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{[(4-methylpiperazin-1-yl)amino]methylidene}-1,6,9,11-tetraoxo-1,2,8,9-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoazeno)naphtho[2,1-b]furan-21-yl acetate

Description:

The chemical substance with the name "(8E,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{[(4-methylpiperazin-1-yl)amino]methylidene}-1,6,9,11-tetraoxo-1,2,8,9-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoazeno)naphtho[2,1-b]furan-21-yl acetate" and CAS number "13983-13-6" is a complex organic compound characterized by multiple functional groups, including hydroxyl, methoxy, and amine functionalities. Its structure suggests significant molecular complexity, featuring a series of methyl groups and a unique naphtho-furan backbone, which may contribute to its biological activity. The presence of tetraoxo groups indicates potential reactivity, while the epoxide moiety suggests the possibility of undergoing ring-opening reactions. This compound may exhibit interesting pharmacological properties due to its structural features, including potential interactions with biological targets. The specific stereochemistry indicated by the (8E,24E) configuration suggests that it may have distinct isomeric forms, which could influence its biological activity and solubility. Overall, this substance represents a class of compounds that may be of interest in medicinal chemistry and drug development.

Formula: C₄₃H₅₆N₄O₁₂

InChI: InChI=1/C43H56N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,44,49-51H,15-18H2,1-10H3/b12-11+,19-14+,22-13+,28-20+,45-33-

InChI key: InChIKey=IHHAOHNZEKYBLG-WLSIYKJHSA-N

SMILES: O=C1C=2C3=C4O[C@@](C)(C3=O)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)NC(C(=O)C2C(O)=C4C)=C1/C=N/N5CCN(C)CC5

Synonyms:

• Rifaldazinequinone
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 1,4-Dideoxy-1,4-dihydro-3-[(E)-[(4-methyl-1-piperazinyl)imino]methyl]-1,4-dioxorifamycin
• Rifamycin, 1,4-dideoxy-1,4-dihydro-3-[(E)-[(4-methyl-1-piperazinyl)imino]methyl]-1,4-dioxo-
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate

RIFAMPICIN QUINONE RS

CAS: 13983-13-6

RIFAMPICIN QUINONE RS

Formula: C₄₃H₅₆N₄O₁₂

Molecular weight: 820.9243

Ref: 41-ICRS0410

RIFAMPICIN QUINONE CRS

CAS: 13983-13-6

RIFAMPICIN QUINONE CRS

Ref: 41-R0800000

Rifampin Quinone (1,4-dideoxy-1,4-dihydro-3-[[[4-methyl-1-piperazinyl]imino]methyl]-1,4-dioxo-rifamycin)

CAS: 13983-13-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₄₃H₅₆N₄O₁₂

Color and Shape: Black Powder

Molecular weight: 820.38947

Ref: 45-1604202

Rifampicin EP Impurity A (Rifampicin Quinone)

CAS: 13983-13-6

Formula: C₄₃H₅₆N₄O₁₂

Color and Shape: Dark Purple Solid

Molecular weight: 820.94

Ref: 4Z-R-2312

Rifampicin Quinone

Controlled Product

CAS: 13983-13-6

Stability Light Sensitive
Applications Rifampicin Quinone is a metabolite of Rifampicin (R508000). Rifampicin Quinone acts as an immunosuppressant unlike Rifampicin.
References Gidoh, M. et al.: Nip. Rai Gak. Zas., 47, 110 (1978); Konrad, P. et al.: Clin. Immunol. Immunopathol., 46,162 (1988); Prasad, B. et al.: J. Pharmac. Biomed. Anal., 50, 475 (2009);

Formula: C₄₃H₅₆N₄O₁₂

Color and Shape: Neat

Molecular weight: 820.92

Ref: TR-R508040

Rifampicin quinone

CAS: 13983-13-6

Rifampicin is a quinone that is used as an antibiotic. It is the most active of the rifamycins for the treatment of tuberculosis. Rifampicin has been shown to have a redox cycle and may be involved in transfer reactions with other biomolecules, such as tenofovir alafenamide hemifumarate (TAF), which is used in HIV therapy. Rifampicin binds to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifampicin also specifically binds to markers expressed at high levels

Formula: C₄₃H₅₆N₄O₁₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 820.93 g/mol

Ref: 3D-NAA98313