CAS 1403783-31-2

Nexturastat A

Description:

Nexturastat A is a small molecule inhibitor primarily known for its role in targeting the enzyme histone deacetylase 6 (HDAC6). This compound is notable for its potential therapeutic applications, particularly in the context of cancer treatment and neurodegenerative diseases. Nexturastat A exhibits characteristics typical of HDAC inhibitors, such as the ability to modulate gene expression by altering histone acetylation status, which can influence cellular processes like proliferation, differentiation, and apoptosis. The compound has shown promise in preclinical studies, demonstrating efficacy in reducing tumor growth and enhancing the effects of other anticancer therapies. Additionally, its selectivity for HDAC6 over other isoforms may contribute to a favorable side effect profile. As a synthetic compound, Nexturastat A's chemical structure includes functional groups that facilitate its interaction with the target enzyme, making it a subject of interest in ongoing research aimed at developing novel cancer therapeutics. Overall, Nexturastat A represents a significant advancement in the field of epigenetic modulation and targeted cancer therapy.

Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-

CAS: 1403783-31-2

Formula: C₁₉H₂₃N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 341.4042

Ref: IN-DA001CB6

4-((1-Butyl-3-Phenylureido)Methyl)-N-Hydroxybenzamide

CAS: 1403783-31-2

4-((1-Butyl-3-Phenylureido)Methyl)-N-Hydroxybenzamide

Purity: 98%

Molecular weight: 341.4g/mol

Ref: 54-OR1022876

Nexturastat A

CAS: 1403783-31-2

Nexturastat A

Purity: ≥98%

Molecular weight: 341.4g/mol

Ref: 54-BUP05587

Nexturastat A

CAS: 1403783-31-2

Ref: 7W-GW3505

Nexturastat A

CAS: 1403783-31-2

Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.

Formula: C₁₉H₂₃N₃O₃

Purity: 99.40% - 99.57%

Color and Shape: Solid

Molecular weight: 341.4

Ref: TM-T1819

NEXTURASTATA

CAS: 1403783-31-2

Purity: 95.0%

Molecular weight: 341.4110107421875

Ref: 10-F468343

Nexturastat A-d5

Controlled Product

CAS: 1403783-31-2

Applications Nexturastat A-d5 is the isotope labelled analog of Nexturastat A (N391500); a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.
References Bergman, J.A., et al.: J. Med. Chem., 55, 9891 (2012)

Formula: C₁₉H₁₈D₅N₃O₃

Color and Shape: Neat

Molecular weight: 200.038

Ref: TR-N391502

Nexturastat A

Controlled Product

CAS: 1403783-31-2

Applications Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.
References Bergman, J.A., et al.: J. Med. Chem., 55, 9891 (2012)

Formula: C₁₉H₂₃N₃O₃

Color and Shape: Neat

Molecular weight: 341.404

Ref: TR-N391500