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CAS 1405-10-3

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Neomycin sulfate

Description:
Neomycin sulfate is an aminoglycoside antibiotic primarily used for its antibacterial properties. It is derived from the bacterium *Streptomyces fradiae* and is effective against a broad spectrum of Gram-negative and some Gram-positive bacteria. The compound is typically administered topically or orally, often in the form of ointments, creams, or eye drops, due to its potential nephrotoxicity and ototoxicity when used systemically. Neomycin sulfate is characterized by its solubility in water, which facilitates its use in various formulations. The chemical structure features multiple amino groups, contributing to its mechanism of action, which involves binding to bacterial ribosomes and inhibiting protein synthesis. Additionally, neomycin sulfate is often combined with other antibiotics or corticosteroids to enhance therapeutic efficacy. It is important to note that resistance to neomycin can develop, limiting its effectiveness in some bacterial infections. As with any antibiotic, appropriate use is crucial to minimize the risk of resistance and ensure optimal therapeutic outcomes.
Formula:H2O4S·xUnspecified
InChI:InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1
Synonyms:
  • (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (1:1)
  • (2S,3S,4S,5S,6S)-5-amino-2-(aminomethyl)-6-[(1S,2S,3S,4R,6R)-4,6-diamino-2-[(2R,3S,4R,5S)-4-[(2S,3S,4S,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol,sulfuric acid
  • Biosol
  • Bykomycin
  • Endomixin
  • Fradiomycin Sulfate
  • Lidamycin Creme
  • Myacine
  • Mycerin sulfate
  • Mycifradin
  • See more synonyms
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