CAS 1405-87-4

Bacitracin

Description:

Bacitracin is a polypeptide antibiotic primarily derived from the bacterium Bacillus subtilis. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a range of Gram-positive bacteria. Bacitracin is often used topically due to its potential nephrotoxicity when administered systemically. The compound is typically found in ointments and creams for treating minor skin infections and is also utilized in some veterinary applications. Bacitracin exhibits a low solubility in water, which influences its formulation and application. Its mechanism of action involves binding to the lipid carrier that transports peptidoglycan precursors across the bacterial membrane, thereby disrupting cell wall formation. While it is effective against certain pathogens, its use is limited due to the risk of resistance development and its toxicity profile. Bacitracin is classified under the ATC code D06AX01 and is recognized for its role in both clinical and agricultural settings, although its systemic use is generally avoided.

Formula: Unspecified

InChI: InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36?,37?,40-,41+,42+,43-,44+,45-,46-,47+,48?,52-,53-,54-/m0/s1

Synonyms:

• (4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methyl-butyl]4,5-dihydrothiazole-5-carbonyl]amino]-4-methyl-pentanoyl]amino]-5-[[(1S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxo-ethyl)-18-(3-aminopropyl)-12-benzyl-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-15-sec-butyl-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid
• Agfivin
• Ai3-50147-X
• Altracin
• Ayfivin
• Baci-Jel
• Baciguent
• Bacillichin
• Bacilliquin
• Baciquent
• Bacitek Ointment
• Bacitracina
• Bacitracine
• Citracin
• Fortracin
• Parentracin
• Penitracin
• Topitracin
• Tropitracin
• Zutracin
• cyclo[N~6~-(N-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}leucyl-alpha-glutamylisoleucyl)-N~2~-asparaginyllysylornithylisoleucylphenylalanylhistidyl-alpha-aspartyl]

Bacitracin

CAS: 1405-87-4

Bacitracin, 1405-87-4, is cyclic polypeptide antibiotic agent derived from Bacillus subtilis which exhibits activity against gram-positive bacteria. Learn more.

Formula: C₆₆H₁₀₃N₁₇O₁₆SZn

Color and Shape: White to pale cream, Powder

Molecular weight: 1488.09

Ref: 02-J62432

Bacitracin

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Purity: 97%

Color and Shape: Solid

Molecular weight: 1422.6933

Ref: IN-DA001CJS

Bacitracin, EP grade

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Purity: ≤ 6.0%

Color and Shape: White or almost white powder

Molecular weight: 1421.60

Ref: 7W-GA9348

Bacitracin

CAS: 1405-87-4

Bacitracin

Color and Shape: off white to faint yellow solid

Ref: 54-BIB0106

Bacitracin

CAS: 1405-87-4

Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis.

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Purity: 60IU/mg - ≥98%

Color and Shape: White To Almost White Powder

Molecular weight: 1422.73

Ref: TM-T1226

Bacitracin

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Purity: ≥ 65IU/mg (dried basis)

Color and Shape: White to light-beige or light-yellow powder

Molecular weight: 1421.60

Ref: 7W-GA3759

Bacitracin, USP grade

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White to pale beige powder

Molecular weight: 1421.60

Ref: 7W-GP3095

Bacitracin

Controlled Product

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆SC₆₅H₁₀₁N₁₇O₁₆S

Color and Shape: Neat

Molecular weight: 0.00

Ref: 04-C10418000

Bacitracin

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Molecular weight: 1422.73

Ref: 4Z-PB-073001

Bacitracin (>80%)

Controlled Product

CAS: 1405-87-4

Applications Bacitracin Zinc is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.
References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);

Formula: C₆₆H₁₀₃N₁₇O₁₆S·3C₆₅H₁₀₁N₁₇O₁₆S

Purity: >80%

Color and Shape: Neat

Molecular weight: 1155.4

Ref: TR-B106500

Bacitracin

CAS: 1405-87-4

Bacitracin is a polypeptide antibiotic and is used for the treatment of bacterial infections, particularly skin infections. It interferes with bacterial cell wall synthesis by inhibiting the dephosphorylation of bactoprenol.

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White Powder

Molecular weight: 1,422.7 g/mol

Ref: 3D-AB30570

Bacitracin (BCT) ex. Bacillus Licheniformis

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White to off - white, Powder, Clear

Molecular weight: 1422.72

Ref: SR-17327

Bacitracin (BCT) ex. Bacillus Licheniformis for cell culture, Endotoxin (BET) 0.05EU/mg

CAS: 1405-87-4

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White to off - white, Powder, Clear

Molecular weight: 1422.72

Ref: SR-33468

Bacitracin

CAS: 1405-87-4

Purity: 97%

Molecular weight: 1421.75

Ref: 10-F557040